Anti-inflammatory Effect of General Anesthesia plus Supraclavicular Peripheral Nerve Blocks After Distal Humeral and Elbow Surgery: Clinical and Labo

Not Applicable

Recruiting

• Conditions: Surgery; Injury, Occupational Diseases, Poisoning; post operative pain in upper limb ORIF in limb fractures; Anaesthesia

• Registration Number: PACTR201711002713192
• Lead Sponsor: Fayoum University Hospitals

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-10-21
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Sixty Patients of both genders ASA ( I¿II - III), aged from 18 to 75 years will be randomly allocated either to receive general anesthesia alone (20) patients group GA , or general anesthesia + supraclavicular block (GAB) (30) patients.

Exclusion Criteria

Exclusion criteria include previous surgery or trauma on the upper limb, current use or previous use of corticosteroids, systemic illness known to affect the inflammatory changes such as rheumatoid arthritis, patients with Congestive heart failure, diabetes mellitus, hypertension, malignancy , patients with coagulopathies or on anticoagulants or antiplatelet therapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cytokine response (inflammatory:IL-6), (TNF-¿ and anti-inflammatory(IL-10) ) ;5-Morphine consumption

Secondary Outcome Measures

Name	Time	Method
1-The circumference and skin temperature of the operated site and contralateral side. ;2-Oedema will be measured thread and compared witth the contralateral side and by oedema score.;3-Pain at rest and at movement will be measured by (VAS) from (0¿10) measured ;4-Healing power of wound: Assessment by Bates-Jensen wound assessment tool (1-13)