Prevention of aortic stenosis pilot trial

Phase 2

Completed

• Conditions: Aortic stenosis; Circulatory System

• Registration Number: ISRCTN17365679
• Lead Sponsor: Queen Mary University of London

Brief Summary

2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/31500854 (added 12/09/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-06-13
• Study Completion: 2018-09-15
• Last Update Posted: 7 October 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

1. Aortic stenosis (Vmax 2.0-4.0 m/s)
2. Age 18-90

Exclusion Criteria

1. Contraindications, including a history of allergy to sevelamer, a history of hypophosphataemia or a history of bowel obstruction
2. A requirement for phosphate binding drugs for other reasons
3. A requirement for drugs that interact with phosphate binding drugs
4. A history of lactose intolerance
5. Any illness judged to contra-indicate participation in the trial
6. Pregnant or breastfeeding women

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum phosphate, measured using standard methods for lab analysis at baseline, 6, 12 and 18 weeks

Secondary Outcome Measures

Name	Time	Method
rine phosphate, measured using standard methods for lab analysis at 6, 12 and 18 weeks