Cognitive training in patients with obsessive-compulsive disorder and neuronal effects

Not Applicable

Recruiting

• Conditions: F42.2; F42.0; F42.1; Mixed obsessional thoughts and acts; Predominantly obsessional thoughts or ruminations; Predominantly compulsive acts [obsessional rituals]

• Registration Number: DRKS00016174
• Lead Sponsor: Humboldt-Universität zu Berlin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

ICD10, F42 (Obsessive-compulsive disorder)

Exclusion Criteria

The following exclusion criteria will be applied to all patients (current and life-time): Co-morbid substance-related disorders, schizophrenia spectrum disorders, delusional disorders, bipolar disorder, neurological disorders of the CNS, verbal IQ < 85. Furthermore, benzodiacepines within the last week, neuroleptics during the last three months will lead to an exclusion.
Exclusion criteria for healthy controls (current and life-time): any mental disorders according to DSM-5, neurological disorders of the CNS, verbal IQ < 85. Furthermore, benzodiacepines within the last week, neuroleptics during the last three months will lead to an exclusion.
All participants must be able to be tested in an MRI, have no disabilities in speaking and must not have any uncorrectable seeing or hearing impairments.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
• Performance (reaction times and error rates) and neuronal activation patterns (blood-oxygen-level-dependent signal) in working memory, measured with functional Magnetic Resonance Imaging (fMRI) during n-back task at measurement time t1 (before training) and t2 (after training).<br>• Performance (reaction times and error rates) and event-related potentials in performance monitoring measured with electroencephalography (EEG) during Flanker task at measurement time t1 and t2.<br>

Secondary Outcome Measures

Name	Time	Method
All measurements at t1 and t2: <br>• OCD (Obsessive-Compulsive Disorder) symptoms measured with SCID-I OCD section, Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Obsessive-Compulsive Inventory-Revised (OCI-R) <br>• Depressive symptoms measured with Beck Depression Inventory II (BDI-II) and Montgomery Asberg Depression Rating Scale (MADRS)<br>• Additional questionnaires: Brief Symptom Inventory (BSI), Beck Anxiety Inventory (BAI), Fragebogen zu exekutiven Funktionen (KATE), Emotion Regulation Questionnaire (ERQ)<br>• Neuropsychological tests: Stroop, Digit Symbol, Digit span, Leistungsprüfsystem – Subtest Figural relations, Trail making test A & B<br>