Microcirculation, Adiposity, and Traditional and Emerging Cardiovascular Risk Factors in Prepubertal Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 98
- 主要终点
- Microvascular reactivity by nail fold videocapillaroscopy
研究概览
简要总结
This is a cross-sectional study aimed to investigate microvascular reactivity in prepubertal children according to adiposity status.
详细描述
The investigators aimed to investigate microvascular reactivity in prepubertal and to compare these data in different groups according to adiposity status. Firstly, The investigators recruited only children from 5 to 10 years at prepubertal status. After excluding those with exclusion criteria and the acceptance (from their parents) to participate in the study, a blood sample was collected and an appointment at BioVasc lab was programmed. At this day, participants were subject to nail fold videocapillaroscopy. A method used to investigate microvascular reactivity by a non-invasive mean. After this, participants children were followed to the outpatient's care unit to continue follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 5 Years 至 10 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •children aged from 5 to 10 years at prepubertal Tanner´s status
排除标准
- •regular use of any medication
- •hypertension
- •heart disease
- •renal and blood diseases .the presence of any acute or chronic inflammatory/infectious diseases. .presence of diabetes mellitus.
结局指标
主要结局
Microvascular reactivity by nail fold videocapillaroscopy
时间窗: 24 months from the beginning of the recruitment period until the ending of the manuscript.
Nailfold videocapillaroscopy is performed using the fourth finger of the left hand in a temperature-controlled environment (22ºC). The following microvascular parameters are determined at resting state: (a) functional capillary density (FCD), the number of capillaries/mm2 with red blood cell flux, evaluated with 250x magnification in a 3-mm area of the distal row of capillaries in three different areas (lateral, central and medial); (b) red blood cell velocity at rest (RBCV) and during post occlusive reactive hyperemia (PORH); c) the peak RBCV after 1-min arterial occlusion (RBCVmax); and (d) the time taken to reach RBCVmax (TRBCVmax). Firstly, a pressure cuff (1-cm wide) is placed around the proximal phalanx and connected to a mercury manometer.
次要结局
- Multivariate analysis using Canonical Discriminant analysis(24 months from the beginning of the recruitment period until the ending of the manuscript.)
- Inflammatory and biochemical biomarkers(24 months from the beginning of the recruitment period until the ending of the manuscript.)
研究者
Luiz Guilherme Kraemer de Aguiar
Associate professor
Rio de Janeiro State University