Pragmatic Clinical Trial of Race-Specific Response to Propofol Infusion Titrated to Effect for Procedural Sedation During Endoscopy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Unconsciousness
- Sponsor
- University of Florida
- Enrollment
- 2780
- Locations
- 1
- Primary Endpoint
- Change in the recovery times among races and ethnicities
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Prospectively evaluate newly established guidelines and make clinicians aware of inter-racial difference in propofol sensitivity.
Detailed Description
The primary motivation in conducting this study is to conduct the implementation science, i.e., formalize and train, and retrain if needed, anesthesia providers in the standard practice of titrating infusion rate to effect and clinically evaluate the effect of race and ethnicity on propofol monotherapy sedation during GI endoscopy. The ultimate goal is to make it less likely that patients from races known to be sensitive to propofol experience inadvertent overdosing.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing propofol sedation at Gainesville (GNV) and Jacksonville (JAX) GI Endoscopy suites
- •Age range 18 - 80 years old
- •Patients whose race can be identified from the electronic patient information chart (EPIC)
Exclusion Criteria
- •Patients who identify as multiracial in Epic
- •Patients who identify as Other in Epic
- •Patients who refuse to indicate their race in Epic
- •Patients whose race is listed as unknown in Epic
Outcomes
Primary Outcomes
Change in the recovery times among races and ethnicities
Time Frame: Change from baseline up to 24 hours
Monitored using aggregate data for metrics of recovery times