Sevoflurane Alone and Propofol With or Without Remifentanil in Electroconvulsive Therapy
Overview
- Phase
- Phase 4
- Intervention
- Propofol
- Conditions
- Anesthesia
- Sponsor
- Inonu University
- Enrollment
- 39
- Locations
- 1
- Primary Endpoint
- Seizure duration
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
To compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane in ECT.
Detailed Description
The purpose of this study is to compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane) with respect to seizure duration, postictal suppression index, early and midictal amplitude, hemodynamic variables and recovery profiles in ECT.
Investigators
Zekine Begec
Principal Investigator
Inonu University
Eligibility Criteria
Inclusion Criteria
- •Upremedicated ASA I-II (American Society of Anesthesiologists's physical status) patients,
- •Patients scheduled for six ECT sessions for a variety of psychiatric conditions (major depression, schizophrenia)
Exclusion Criteria
- •Involuntary patient status
- •Patients with known or self-declared needle or mask phobia
- •Pregnancy
- •Cerebrovascular disease,
- •History of myocardial infarction in the previous 6 months,
- •Atrial fibrillation or flutter,heart block,
- •A known or family history of reactions to the study drugs.
Arms & Interventions
propofol (Group P)
The patients in Group P received 1 mg/kg propofol IV (over 15 sec) during anesthesia induction
Intervention: Propofol
remifentanil and propofol (Group R)
Patients in Group R received remifentanil 1 µg/kg IV (over 60 sec) and 0.5 mg/kg propofol IV (over 15 sec)during anesthesia induction
Intervention: Remifentanil and propofol
sevoflurane (Group S)
In Group S, sevoflurane was started at 6% for induction and continued at 1% until the electrical stimulus was delivered, at which time it was stopped.
Intervention: Sevoflurane
Outcomes
Primary Outcomes
Seizure duration
Time Frame: The patients were observed about seizure up to ten minutes after electrical stimulation
After anesthesia induction patients were administered electrical stimulation and seizure duration were measured.
Secondary Outcomes
- postictal suppression index(completing seizure in one hour)
- Recovery parameters (spontaneous breathing, eye opening, and obeying of verbal commands)(after seizure in one hour in operation room.)
- Hemodynamic variables(Before administration of the study medications (t0), and at 1 (t1), 3 (t2), and 10 (t3) minutes after the seizure ended.)