Comparison of Left and Right Ventricular Geometry and Functional Parameters in Chronic Fatigue Syndrome Patients versus Age- and Sex- Matched Healthy Controls Assessed by Cardiovascular Magnetic Resonance Imaging.
Completed
- Conditions
- 10019280chamber functionheart function
- Registration Number
- NL-OMON39100
- Lead Sponsor
- Medisch Spectrum Twente
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
Healthy female volunteers, age range 20-60 years.
Able to provide informed consent.
Exclusion Criteria
Previous cardiovascular disease
known diseases with cardiac involvement
Unwillingness to use or contra-indications for contrast agents
Age < 20 or > 60 years
Pregnancy
Breast feeding
Kidney dysfunction
Body mass index > 30
Claustrophobia or other exclusion criteria for MRI such as implanted metal materials
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters will be LV and RV geometry and function (i.e., LV and<br /><br>RV end-diastolic volume, end-systolic volume, end-diastolic wall mass, wall<br /><br>motion score and ejection fraction) and tissue characterization of the<br /><br>myocardium, to assess presence and extent of CE. </p><br>
- Secondary Outcome Measures
Name Time Method <p>To assess the level of activity* in the healthy female volunteers in order to<br /><br>correspond with the physically inactive CFS population and to assess if small<br /><br>expected differences in LV/RV geometry, function and tissue characterization in<br /><br>the female healthy subgroup can be explained by individual level of activity.<br /><br><br /><br>* The level of activity in the individual healthy volunteers is quantitatively<br /><br>determined by (1) using a validated questionnaire and (2) completing a bicycle<br /><br>exercise test.</p><br>