Influence between weight loss and improvement of symptoms in patients with reflux disease to the esophagus (occurs when the stomach contents back to the esophagus)
Not Applicable
- Conditions
- Gastroesophageal reflux disease and obesity
- Registration Number
- RBR-3cfcyc
- Lead Sponsor
- niversidade Federal do Rio Grande do Sul - UFRGS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Both sexes; age over 18 years; BMI greater than 25m ² / kg; that are experiencing typical symptoms (heartburn or regurgitation) 1 x per week or more;presence of diagnosis, confirmed by endoscopy and treatment of GERD; voluntary agreement to participate in the study.
Exclusion Criteria
Hospitalized patients; pregnant / lactating;
patients who underwent surgery of the esophagus and / or stomach; cognitive inability to understand the guidelines;
chronic diseases such as cancer and diabetes mellitus;presence of hiatal hernia;
refractory to drug treatment; presence of complicated GERD with esophagitis grade C or D;
presence of Barrett's esophagus; patient's wish to opt for surgical treatment.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of symptoms of gastroesophageal reflux disease.<br>Participants answered the QS-GERD Symptoms Questionnaire of Gastroesophageal Reflux Disease (GERD-QS) in which the maximum score is 55 points. This questionnaire consists of 11 questions, 10 of them answered according to a scale of 0 to 5, with the following meanings: 0, absence of symptoms; 1, symptoms without repercussion no day-to-day patient; and so gradually ate 5 indicates que que constants symptoms interfere with daily activities of patients.<br>Statistical analysis were considered the first and last assessment to which each patient was submitted. The comparison between groups was performed by Student's t test. To control confounding factors, Analysis of Covariance (ANCOVA) was applied. The significance level was 5% (p 0.05).<br>
- Secondary Outcome Measures
Name Time Method Improvement of symptoms of gastroesophageal reflux disease.<br>Participants answered the QS-GERD Symptoms Questionnaire of Gastroesophageal Reflux Disease (GERD-QS) in which the maximum score is 55 points. This questionnaire consists of 11 questions, 10 of them answered according to a scale of 0 to 5, with the following meanings: 0, absence of symptoms; 1, symptoms without repercussion no day-to-day patient; and so gradually ate 5 indicates que que constants symptoms interfere with daily activities of patients.<br>Statistical analysis were considered the first and last assessment to which each patient was submitted. The comparison between groups was performed by Student's t test. To control confounding factors, Analysis of Covariance (ANCOVA) was applied. The significance level was 5% (p 0.05).<br>