Eggs as Nutrient-Rich Source of Protein to Enhance Activity-Related Health in Older Persons: The Eggs and actiVity in hEalth agiNg Pilot (EVEN-P) Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Sponsor
- McMaster University
- Locations
- 1
- Primary Endpoint
- Dietary protein intake.
Study Overview
Brief Summary
Two of the most effective lifestyle-based approaches to reduce the risk of adverse health events and enhance quality of life with aging are exercise and a healthy diet. Currently, the Canadian recommended dietary allowance (RDA) for protein is 0.8 g/kg/day, however, several expert groups have advocated for a higher RDA of protein (~1.2 g/kg/day), along with more evenly distributed daily consumption, in older persons. Eggs are considered a nutrient-rich protein source but have recently been scrutinized. This study will compare a high-protein, egg-containing diet and a high-protein, non-egg diet in healthy older persons.
Detailed Description
This study will examine the impacts of an egg-containing diet and a non-egg diet in healthy older persons. Briefly, participants (healthy persons, age 60-75 years old) will consume their normal diet or their normal diet plus 4 eggs completing a structured exercise program (designed to meet Canada's Physical Activity Guidelines) for a total of 12 weeks. Participants will be randomly assigned to the Egg or Control (non-egg) group. Before and after the 12-week intervention, participants' undergo assessments of diet-quality, muscle health, fitness, bone health, and vascular health.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 60 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Exclusion Criteria:
- •Use assistive walking devices (e.g. cane or walker)
- •Consume any analgesic (pain-relieving) or anti-inflammatory drug(s), prescription or non-prescription, chronically
- •A history of neuromuscular problems or muscle-wasting diseases
- •Any acute chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders- all ascertained through medical screening questionnaires
- •Chronic consumption of statins (particularly simvastatin/Zocor and atorvastatin/Lipitor) used to lower cholesterol
- •Be on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription-strength acne medications)
- •Have allergies or are not willing to consume eggs
- •Consume a vegetarian diet
- •Had significant weight gain or loss in the past 6 months
- •Have injuries preventing the safe completion of the exercise
Exclusion Criteria
- •Use assistive walking devices (e.g. cane or walker)
- •Consume any analgesic (pain-relieving) or anti-inflammatory drug(s), prescription or non-prescription, chronically
- •A history of neuromuscular problems or muscle-wasting diseases
- •Any acute chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders- all ascertained through medical screening questionnaires
- •Chronic consumption of statins (particularly simvastatin/Zocor and atorvastatin/Lipitor) used to lower cholesterol
- •Be on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription-strength acne medications)
- •Have allergies or are not willing to consume eggs
- •Consume a vegetarian diet
- •Had significant weight gain or loss in the past 6 months
- •Have injuries preventing the safe completion of the exercise
Arms & Interventions
Exercise
Exercise
Intervention: Exercise (Behavioral)
Exercise + Diet
Exercise + eggs
Intervention: Exercise plus diet (egg) (Behavioral)
Outcomes
Primary Outcomes
Dietary protein intake.
Time Frame: Pre- and post-intervention over 12 weeks
Dietary protein intake (specifically meal-to-meal distribution) will be measured in all participants using a 3-day food log.
Secondary Outcomes
- Change in lean mass(Pre- and post-intervention over 12 weeks)
- Strength(Pre- and post-intervention over 12 weeks)
- Vascular health(Pre- and post-intervention over 12 weeks)
- Change in body fat mass(Pre- and post-intervention over 12 weeks)
Investigators
Stuart Phillips
Professor
McMaster University