Non-Invasive Assessment of Intracoronary Thrombosis in Patients With Acute Coronary Syndrome and Chronic Stable Angina Using Magnetic Resonance Imaging.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- Evidence of high intensity signals within the coronary arteries on T1 weighted magnetic resonance imaging.
研究概览
简要总结
This study involves the use of Magnetic Resonance Imaging (MRI) to determine whether blood clots can be identified within the blood vessels supplying blood to the heart in patients with angina and who have recently suffered a heart attack.
详细描述
The majority of heart attacks are caused as a result of small blood clots forming within the blood vessels supplying blood to the heart, obstructing blood flow to the heart muscle. Research has also shown that blood clots may form in the blood vessels of the heart without causing a heart attack. At present, blood clots may be identified by techniques used during invasive coronary angiography, but we wish to determine whether a non-invasive test (MRI scanning) can be used to detect small blood clots within the blood vessels supplying blood to the heart muscle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged over 18 years
- •Previously diagnosed coronary artery disease undergoing elective invasive angiography (Cohort 1) OR
- •Admitted with Acute Coronary Syndrome (ACS) diagnosed by two of the following criteria;
- •Elevation of cardiac biomarkers (high sensitivity troponin I greater than 34ng/l in men and 16ng/l in women).
- •Symptoms of myocardial ischaemia
- •Electrocardiogram (ECG) changes indicative of acute ischaemia (Cohort 2)
- •Planned invasive coronary angiography
排除标准
- •Contraindication or inability to undergo MRI scanning
- •Renal failure (estimated glomerular filtration rate less than 30millilitres/minute)
- •Undergoing Primary Percutaneous Coronary Intervention
- •Ongoing myocardial ischaemia or dynamic ECG changes
- •Inability to provide informed consent
- •Known allergy to gadolinium based contrast
- •Women who are pregnant, breastfeeding or of child-bearing potential
结局指标
主要结局
Evidence of high intensity signals within the coronary arteries on T1 weighted magnetic resonance imaging.
时间窗: Within 72 hours prior to angiography
次要结局
- The correlation between high risk plaques as determined on MRI with culprit plaques on invasive angiography in patients with acute coronary syndrome (ACS).(Through study completion, an average of 1 year)
- The change in plaque signal intensity on magnetic resonance imaging at three months following acute coronary syndrome (ACS).(Baseline and 3 months)
- Incidence of intracoronary thrombosis, as detected by magnetic resonance imaging, in patients with stable coronary artery disease.(Through study completion, an average of 1 year)
- The change in plaque signal intensity on magnetic resonance imaging at one month following acute coronary syndrome (ACS).(Baseline and 1 month)