Difference in morning cortisol levels of statin-treated diabetic patients with varied levels of controlled low-density lipoprotein cholesterol
Not Applicable
Completed
- Conditions
- Type 2 DM-patients with type 2 DM-on statin treatmentstatin
- Registration Number
- TCTR20180924003
- Lead Sponsor
- Thammasat university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 76
Inclusion Criteria
1. age 18 year-old or more
2. Type 2 DM
3. on constant statin-dose more than 3 months
4. Difference in LDL-C level less than 30% within 1 year before recruiting to the study
5. Able to inform and consent
Exclusion Criteria
1.No history of steroid use within 6 months before recruiting to the study
2.No history of drug interfering cortisol metabolism
3.Diagnosed with adrenal insufficiency or Cushing syndrome
4.glomerular filtration rate < 30 ml/min/1.73 m2
5.cirrhosis
6.Serum albumin < 2.5 mg/dl
7.During acute illness
8.Abnormal thyroid function
9.contraceptive pill
10.On lipid-lowering treatments other than statin
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method serum cortisol level at the day of enrollment microgram/deciliter
- Secondary Outcome Measures
Name Time Method serum cortisol level after ACTH stimulation test at the day of enrollment microgram/deciliter