Comparison of Different Types of Resistant Starch

Not Applicable

Completed

• Conditions: Postprandial Hyperglycemia
• Interventions: Dietary Supplement: Resistant Starch

• Registration Number: NCT00930956
• Lead Sponsor: Kansas State University

Brief Summary

This study is to determine whether different types of resistant starch have different effects on blood glucose in healthy adults.

Detailed Description

Each volunteer will visit the laboratory in a 10-12 hour fasted state on three occasions over a three-week period, up to two visits/wk, with at least 48 hours between visits. Volunteers will be asked to refrain from vigorous physical activity and the consumption of alcohol the day before each testing visit. Randomization using a Latin Square design was applied to minimize confounding issues associated with the order of administration.

In the morning of each test, a finger-prick capillary blood samples will be collected to determine fasting (baseline) blood glucose levels. The volunteers will then consume the test solution assigned for that trial. Ten minutes will be allowed for the test solution to be consumed. Over the two hours following the start of each test, finger-prick capillary blood samples were collected at 30, 60, 90, and 120 min. Blood glucose levels will be immediately measured in duplicate using an automated blood glucose analyzer (YSI 2300, Yellow Springs, OH). Analysis of the collected sample was repeated if the difference between duplicate samples was greater than 0.1 mmol/L. Once the samples were analyzed, the data was entered and the incremental area under the curve was calculated using the trapezoidal model (GraphPad v5.0, La Jolla, CA).

Study Timeline

• Study Start: 2006-05
• Primary Completion: 2009-05
• Study Completion: 2009-05
• Status Verified: 2009-06
• Study First Submitted: 2009-06-30
• Study First Submitted QC: 2009-06-30
• Study First Posted: 2009-07-02
• Last Update Submitted: 2010-07-28
• Last Update Posted: 2010-07-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• apparently healthy

Exclusion Criteria

• diagnosis of any chronic disease
• wheat allergy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Dextrose	Resistant Starch	30 g of carbohydrate via Sun-Dex OGTT beverage
RS Type 2	Resistant Starch	30g Resistant Starch Type 2 (Hi-Maize 260, National Starch)
RS Type 4 (cross linked)	Resistant Starch	30g of cross linked RS type 4 (Fibersym RW, MGP Ingredients, Inc.)

Primary Outcome Measures

Name	Time	Method
Blood glucose	Acute response -- fasting and 30, 60, 90 and 120 minutes post-ingestion

Trial Locations

Locations (1)

Human Metabolism Laboratory (K-State Univ.); 🇺🇸 Manhattan, Kansas, United States