The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Postprandial muscle protein synthesis
研究概览
简要总结
The present study will seek to quantify the muscle protein synthetic response to a protein beverage consumed orally or through a nasogastric tube in healthy, young individuals.
详细描述
Thirty healthy, young volunteers will receive a stable isotope tracer infusion (8.5h) combined with repeated blood and muscle sampling, in order to measure muscle protein synthesis rate in the postabsorptive state, and following oral placebo ingestion (n=10), oral protein ingestion (n=10), or enteral protein administration (n=10).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
Oral conditions are double blinded to participant and investigator, but enteral vs oral feeding is not blinded
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-40 years of age
- •Body mass index between 18.5 and 30
排除标准
- •Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
- •Any diagnosed cardiovascular disease
- •Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140 mmHg over two or more measurements and an average diastolic blood pressure of ≥90 mmHg over two or more measurements)
- •Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism). This excludes oral contraceptives and contraceptive devices.
- •A personal or family history of epilepsy, seizures or schizophrenia.
- •Presence of an ulcer in the stomach or gut and/or strong history of indigestion
- •Known pre-existing liver disease/condition
- •Any known disorders in muscle metabolism
- •Regular use of nutritional supplements
- •Allergy to lidocaine
- •Allergy to milk
- •Current paracetamol use (i.e. use of paracetamol more than once a week)
- •Pregnancy
研究组 & 干预措施
Oral Placebo
Placebo drink
干预措施: Oral Placebo (Other)
Oral Protein
Protein drink, ingested orally
干预措施: Oral Protein (Other)
Enteral Protein
Protein drink, administered via enteral tube
干预措施: Enteral Protein (Other)
结局指标
主要结局
Postprandial muscle protein synthesis
时间窗: 5 hours
Muscle protein synthesis rate (FSR) following ingestion of a placebo or protein supplement
次要结局
- Postabsorptive muscle protein synthesis(2 hours)
- Whole-body protein synthesis(7 hours)
- Whole-body protein breakdown(7 hours)
- Whole-body protein oxidation(7 hours)
- Whole-body protein net balance(7 hours)
- Gastric emptying rate(5 hours)
- Blood glucose concentration(8.5 hours)
- Serum insulin concentration(8.5 hours)