NCT03571425
Completed
Not Applicable
The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females
ConditionsHealthy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- University of Exeter
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Postprandial muscle protein synthesis
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The present study will seek to quantify the muscle protein synthetic response to a protein beverage consumed orally or through a nasogastric tube in healthy, young individuals.
Detailed Description
Thirty healthy, young volunteers will receive a stable isotope tracer infusion (8.5h) combined with repeated blood and muscle sampling, in order to measure muscle protein synthesis rate in the postabsorptive state, and following oral placebo ingestion (n=10), oral protein ingestion (n=10), or enteral protein administration (n=10).
Investigators
Eligibility Criteria
Inclusion Criteria
- •18-40 years of age
- •Body mass index between 18.5 and 30
Exclusion Criteria
- •Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
- •Any diagnosed cardiovascular disease
- •Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140 mmHg over two or more measurements and an average diastolic blood pressure of ≥90 mmHg over two or more measurements)
- •Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism). This excludes oral contraceptives and contraceptive devices.
- •A personal or family history of epilepsy, seizures or schizophrenia.
- •Presence of an ulcer in the stomach or gut and/or strong history of indigestion
- •Known pre-existing liver disease/condition
- •Any known disorders in muscle metabolism
- •Regular use of nutritional supplements
- •Allergy to lidocaine
Outcomes
Primary Outcomes
Postprandial muscle protein synthesis
Time Frame: 5 hours
Muscle protein synthesis rate (FSR) following ingestion of a placebo or protein supplement
Secondary Outcomes
- Postabsorptive muscle protein synthesis(2 hours)
- Whole-body protein synthesis(7 hours)
- Whole-body protein breakdown(7 hours)
- Whole-body protein oxidation(7 hours)
- Whole-body protein net balance(7 hours)
- Gastric emptying rate(5 hours)
- Blood glucose concentration(8.5 hours)
- Serum insulin concentration(8.5 hours)
Study Sites (1)
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