NT-proBNP Levels in the Prediction of Intrapartum and Postpartum Events in Adult Congenital Heart Disease Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Congenital Heart Disease
- Sponsor
- Mayo Clinic
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- Postpartum cardiac complications
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The purpose of this study is to determine if NT-BNP levels obtained at time of admission for delivery are predictive of intrapartum or postpartum complications in patients with adult congenital heart disease.
Detailed Description
Amino-terminal pro-B-type natiuretic peptide (NT-proBNP) is a prohormone released from cardiac ventricular myocytes in direct response to cardiac workload. Secreted in the biologically inactive form, NT-proBNP is cleaved in the circulation into BNP, which subsequently exerts both vasodilatory and diuretic effects. The principal clinical utility of serum NT-proBNP measurement has been as an adjunctive marker in the diagnosis of subclinical heart failure, with higher levels typically reflective of increasing cardiac dysfunction. The proposed prospective cohort study intends to collect serum NT-proBNP levels in singleton ACHD patients and a comparative normotensive control group at time of admission for delivery to characterize negative predictive values for intrapartum and postpartum cardiac events. Both pregnant patients with previously-diagnosed ACHD and those diagnosed and delivering during the study interval will be candidates for participation, and a gestational age threshold of 37 weeks will be utilized for the control group.
Investigators
Carl H. Rose
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •Pregnant adult women ages 18 - 50
- •Pregnancy with congenital heart disease (study group) or without congenital heart disease (control group)
Exclusion Criteria
- •Non-pregnant patients
- •Non-English-speaking patients
- •Maternal age \<18 years or \>50 years
- •Patients with hypertensive complications of pregnancy
- •Maternal peripartum cardiomyopathy
- •Multiple gestation
Outcomes
Primary Outcomes
Postpartum cardiac complications
Time Frame: Initial 96 hours following delivery of infant(s)
Incidence of heart failure, incidence of arrhythmia, incidence of cardiac arrest
Intrapartum cardiac complications
Time Frame: Inpatient admission for subsequent 48 hours
Incidence of heart failure, incidence of arrhythmia, incidence of cardiac arrest
Secondary Outcomes
- Intrapartum obstetrical complications(Inpatient admission for subsequent 48 hours)
- Postpartum obstetrical complications(Initial 96 hours following delivery of infant(s))