Comparing the two anesthetic drugs ( ketamine and dexmedetomidine) during the operative period in reducing the analgesic drug (opioid) requirement during the operative period using Surgical Plethysmo graphic Index (SPI) based nociception monitoring in patients undergoing lumbar spine surgeries.
Phase 3
Not yet recruiting
- Conditions
- Health Condition 1: O- Medical and Surgical
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Adult patient aged 18-70 years belonging to either sex.
2. American society of anesthesiologists.
Exclusion Criteria
1. Allergy to any of the drugs used in the study including ketamine and dexmedetomidine.
2. Raised intracranial and intraocular pressure.
3. ischemic heart disease and uncontrolled hy-pertension.
4. History of psychosis and seizure disorder.
5. Hepatic and renal impairment.
6. History of possibility of postoperative delir-ium patients (eg: delirium tremons, possibility of head trauma).
7.History of Porphyria disorder.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of intraoperative fentanyl requirement between the groups based on SPI based nociception monitoring.Timepoint: Intraoperative period
- Secondary Outcome Measures
Name Time Method Comparison of recovery characteristics between the groups using Quality of Recovery15 (QoR15) score at the end of 24 hours in the postoperative period. <br/ ><br>Timepoint: Postoperative period;Comparison of the time to extubating between the groups. <br/ ><br> <br/ ><br>Timepoint: Intraoperative period;Comparison of the total fentanyl consumption between the groups during the first 24hrs in the postoperative period using patient-controlled analgesia. <br/ ><br> <br/ ><br>Timepoint: Postoperative period