A study on the efficacy of treatment of Dry mouth syndrome accompanied by Laryngopharyngeal Reflux Disease with or without additional Ilaprazole administratio
- Conditions
- Diseases of th respiratory system
- Registration Number
- KCT0003888
- Lead Sponsor
- Inha University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 172
(1)Men or Women between the ages of 18 and 80
(2)Patients having dry mouth and symptoms of Laryngopharyngeal reflux disease observed by Laryngoscope and with the chronic symptoms such as globus pharyngis, heartburn, voice change, pain, hoarseness, dysphagia, cough
(3)Those who heard the explanation of this clinical trial and decided to voluntarily participate and signed the consent form
Those with hypersensitivity to Proton pump inhibitor including Ilaprazole
(2) Those with the history of malignant tumor of the larynx
(3) Those with the history of Head and Neck radiation therapy and diagnosed with Sjogren’s Syndrome
(4) Those with need to constantly take Steroids or Non steroidal anti inflammatory drugs including Aspirin (more than 325mg/d), Warfarin, Coumarin.
(5) Those who took Prokinetics, Steroids 7 days before evaluation of saliva secretion.
(6) Those who used chemical compound inhaler
(7) Those who has undergone surgery or treatment for Gastroesophageal reflux disease.
(8) Those who has undergone gastric acid suppression surgery or gastro-duodenal surgery.
(9) Those who has undergone major surgery affecting gastric acid secretion except surgery such as appendectomy, cholecystectomy, hysterectomy.
(10) Current Zollinger-Ellison Syndrome patient and alcohol addictor or those with the history of drug abuse.
(11) Pregnant and lactating women
(12) Childbearing women (Menopausal women who are amenorrheic for at least 12 months are considered to be non-childbearing women)
(13) Those who participated in other clinical trial within 30 days before Screening.
(14) Those who are judged to be improper for this clinical trial.
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Questionnaire on dry mouth;Volume and rate of Saliva Secretion
- Secondary Outcome Measures
Name Time Method Reflux Symptom Index;Reflux Finding SAcore