Comparison and evaluation of improvement of dry mouth and laryngopharyngel reflux in Sjogren´s syndrome patients by administration of Ilaprazole
- Conditions
- Diseases of the musculoskeletal system and connective tissue
- Registration Number
- KCT0008138
- Lead Sponsor
- ational Health Insurance Service Ilsan Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- All
- Target Recruitment
- 24
(1) Adults between the ages of 19 and 80
(2) Patients diagnosed with Sjogren's syndrome
(3) Patients with symptoms of dry mouth and pharyngeal reflux on laryngoscopy
(4) A person who has listened to the explanation of this clinical study, voluntarily decided to participate and signed the consent form
(1) Persons with hypersensitivity to PPI drugs
(2) Patients with asthma, hypersensitivity to pilocarpine, acute iritis or narrow-angle glaucoma (right-angle glaucoma)
(3) Those with a history of malignant tumors of the larynx in the past
(4) Those who need to continuously take non-steroidal anti-inflammatory drugs (NSAIDs) or steroids including Warfarin, Coumarin, and Aspirin (more than 325 mg/d) during the test period
(5) Those who took gastric motility stimulants, antacids, steroids, or NSAIDs 7 days before the measurement of salivation
(6) Those who smoke or drink alcohol or use chemical inhalants on the day of admission
(7) Those who have undergone surgery or treatment for gastroesophageal reflux disease (GERD)
(8) Those who have undergone gastric acid secretion suppression surgery or gastric or duodenal surgery
(9) Those who have undergone major surgery that may affect gastric acid secretion, except for surgeries such as appendectomy, cholecystectomy, and hysterectomy
(10) Current patients with Zollinger-Ellison Syndrome and those who are alcoholics or have a history of substance abuse
(11) Pregnant women, pregnant women, and lactating women
(12) Those who have participated in other clinical trials within 3 months before screening
(13) Patients who were judged unsuitable for participation in the study by other researchers
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in dry mouth questionnaire scores and salivary flow test score after treatment
- Secondary Outcome Measures
Name Time Method Changes in reflux symptom index and reflux finding score after treatment