Protein Extrusion and Postprandial Amino Acid Handling

Not Applicable

Completed

• Conditions: Postprandial Plasma Amino Acid Availability
• Interventions: Dietary Supplement: Dry protein blend ingestion; Dietary Supplement: Extruded protein blend ingestion

• Registration Number: NCT05584358
• Lead Sponsor: University of Exeter

Brief Summary

The bulk of research that has investigated the effect of dietary protein on muscle tissue in humans has used isolated, minimally processed protein powders. However, the protein that we consume on a daily basis has typically undergone various processing methods, and evidence suggests these can change the way our bodies metabolise the protein. 'Extrusion' is a common processing method that uses high pressure to produce protein containing cereals and meat replacement foods. There is currently no research looking at how extrusion affects the way a protein source is digested and absorbed in humans. This study will compare the availability of ingested protein in the blood in the hours following consumption of an extruded versus a non-extruded source.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-01-24
• Study Start: 2022-02-02
• Study First Submitted QC: 2022-10-17
• Study First Posted: 2022-10-18
• Primary Completion: 2023-08-31
• Study Completion: 2023-08-31
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-10
• Last Update Posted: 2024-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

• BMI between 18 and 30.
• Metabolically healthy

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Exclusion Criteria

• Any metabolic impairments
• cardio/pulmonary diseases.
• Chronic use of the over the counter medicine
• A personal or family history of epilepsy, seizures or schizophrenia.
• Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Dry Blend	Dry protein blend ingestion	A dry blend of mycoprotein and pea protein.
Extrudate	Extruded protein blend ingestion	An extruded blend of mycoprotein and pea protein

Primary Outcome Measures

Name	Time	Method
Plasma amino acid concentrations	5 hours	The rate of appearance of amino acids ingested in the drink

Secondary Outcome Measures

Name	Time	Method
Blood glucose	5 hours	The concentrations of glucose in the blood
Resting metabolic rate	5 hours	The amount of energy used to digest the protein
Serum insulin	5 hours	The concentration of insulin in the blood

Trial Locations

Locations (2)

University of Exeter; 🇬🇧 Exeter, Devon, United Kingdom

Sport & Health Sciences University of Exeter; 🇬🇧 Exeter, Devon, United Kingdom