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Clinical Trials/NCT05584358
NCT05584358
Completed
Not Applicable

The Impact of the Extrusion Process During Dietary Protein Production on in Vivo Postprandial Amino Acid Availability

University of Exeter2 sites in 1 country9 target enrollmentFebruary 2, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Postprandial Plasma Amino Acid Availability
Sponsor
University of Exeter
Enrollment
9
Locations
2
Primary Endpoint
Plasma amino acid concentrations
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

The bulk of research that has investigated the effect of dietary protein on muscle tissue in humans has used isolated, minimally processed protein powders. However, the protein that we consume on a daily basis has typically undergone various processing methods, and evidence suggests these can change the way our bodies metabolise the protein. 'Extrusion' is a common processing method that uses high pressure to produce protein containing cereals and meat replacement foods. There is currently no research looking at how extrusion affects the way a protein source is digested and absorbed in humans. This study will compare the availability of ingested protein in the blood in the hours following consumption of an extruded versus a non-extruded source.

Registry
clinicaltrials.gov
Start Date
February 2, 2022
End Date
August 31, 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • BMI between 18 and
  • Metabolically healthy

Exclusion Criteria

  • Any metabolic impairments
  • cardio/pulmonary diseases.
  • Chronic use of the over the counter medicine
  • A personal or family history of epilepsy, seizures or schizophrenia.
  • Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.

Outcomes

Primary Outcomes

Plasma amino acid concentrations

Time Frame: 5 hours

The rate of appearance of amino acids ingested in the drink

Secondary Outcomes

  • Blood glucose(5 hours)
  • Resting metabolic rate(5 hours)
  • Serum insulin(5 hours)

Study Sites (2)

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