Effect of Administering Intravenous Magnesium Sulfate Heptahydrate (MgSO4•7H2O) on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients in 3rd Trimester of Pregnancy
试验速览
- 阶段
- 4 期
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Fetal heart rate tracing
研究概览
简要总结
Admission CTG for 20 minutes Settings on a CTG machine was standardised to enable a consistent approach of interpretation of traces. Paper speed of 3cm per minute will be adopted. Maternal heart rate was recorded and noted on CTG. Following birth date, time and mode of delivery will be labelled on CTG.
Magnesium sulphate was administered by continuous intravenous infusion according to our hospital protocol as follows:
- Loading dose: 4-6 gm of magnesium sulphate diluted in 100 mL of IV fluid administered over 15-20 min.
- Maintenance dose: 2 gm/hr in 100 mL of IV infusion to be continued for 24 hours after delivery.
Another 20 minutes CTG strip will be performed 20 minutes after administration of IV loading MgSO4, 7H2O and thus ensuring that MgSO4 has reached peak serum levels
详细描述
Admission CTG:
Admission CTG will be performed for 20 minutes
I-Settings:
- Settings on a CTG machine will be standardised to enable a consistent approach of interpretation of traces.
- Paper speed of 3cm per minute will be adopted.
- CTGs will be labelled with mother's name, hospital number.
- Date and time settings on machines will be labelled at commencement of tracing.
- Maternal heart rate will be recorded and noted on CTG.
- Following birth date, time and mode of delivery will be labelled on CTG.
Magnesium Sulphate hepatahydrate administration:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnant Women in the third trimester.
- •Severely preeclamptic patients.
- •Singleton Pregnancy.
- •Patients with normal admission CTG
排除标准
- •Evidence of fetal anomalies on scan.
- •Concomitant maternal morbidities as diabetes, cardiac disease.
- •Patients contraindicated to take MgSo4 e.g.: advanced renal disease.
- •Abnormal admission CTG.
- •Morbid obesity.
研究组 & 干预措施
MgSO4
Magnesium sulphate was administered by continuous intravenous infusion according to our hospital protocol as follows:
- Loading dose: 4-6 gm of magnesium sulphate diluted in 100 mL of IV fluid administered over 15-20 min.
- Maintenance dose: 2 gm/hr in 100 mL of IV infusion to be continued for 24 hours after delivery.
干预措施: MgSO4 (Drug)
结局指标
主要结局
Fetal heart rate tracing
时间窗: 20 minutes after MgSO4 administration
Settings on a CTG machine is standardised to enable a consistent approach of interpretation of traces. Paper speed of 3cm per minute is adopted
次要结局
未报告次要终点