FKBP51s: a New Molecular Biomarker for Glioblastoma? Pre- and Post-operative Blood Levels Evaluation of FKBP51s Protein and Correlation With MRI Phenotype

Not Applicable

Recruiting

• Conditions: Glioblastoma
• Interventions: Diagnostic Test: Blood sample

• Registration Number: NCT05793021
• Lead Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Brief Summary

The aim of this interventional study is to investigate the correlation between Magnetic Resonance Phenotype and levels of FKBP51s protein pre and post surgery in adult patients affected by Glioblastoma

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2021-07-08
• Status Verified: 2023-02
• Study First Submitted: 2023-02-20
• Study First Submitted QC: 2023-03-29
• Last Update Submitted: 2023-03-29
• Study First Posted: 2023-03-31
• Last Update Posted: 2023-03-31
• Primary Completion: 2023-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Age >= 18 years
• Diagnosis of Glioblastoma with surgery criteria
• Brain MRI with contrast both pre and post surgery

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Exclusion Criteria

• No availability of radiological documentation
• Glioblastoma diagnosis not confirmed by Histological examination
• Withdrawal of ICF

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Single arm	Blood sample	-

Primary Outcome Measures

Name	Time	Method
Correlation between FKBP51s protein concentration in Blood Cells and Disease flow	3 months

Secondary Outcome Measures

Name	Time	Method
Correlation between FKBP51s protein concentration in Blood Cells and PDL1 expression, Brain MRI phenotype and survival	1 year

Trial Locations

Locations (1)

Fondazione Policlinico Universitaro "A. Gemelli" IRCCS; 🇮🇹 Roma, Italy