The influence of MAC values and behaviour of a child on emergence delirium after sevoflurane anesthesia

Completed

• Conditions: postoperatieve gedragsstoornissen na sevoflurane anesthesie; emergence delirium; 10012221

• Registration Number: NL-OMON34222
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

age between 1,5-6 years
children scheduled for MRI scan onder general anesthesia
no premedication
ASA status 1-2
parents who speak Dutch
parents present during anesthesia induction
written informed consent

Exclusion Criteria

Cognitive or emotional developmental disorder, with exception of attention deficite hyperactivity disorder.
Use of active ingredients which influence the central nervous system (anticonvulsants)
Risk of malignant hyperthermia
Hypersensitivity to sevoflurane or propofol
Need for premedication

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary research question:<br /><br><br /><br>Is it possible that adapting the amount of sevoflurane, from 1 MAC (2,5 vol%)<br /><br>to * MAC (1,25 vol%) in an MRI scan can reduce the frequency and gravity of ED?</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary research questions:<br /><br><br /><br>1.Do the anxiety of the parents (measured by the APAIS), the anxiety of the<br /><br>child at induction (measured by the m-YPAS) and the behaviour (measured by the<br /><br>CBCL 11/2-5) constitute a predictive value for the appearance of ED (measured<br /><br>with the PAED scale)?<br /><br>2.In case significant ED appears, can this lead to an increase of behavioural<br /><br>disorders (measured by the PHBQ) at 1 day, 1 week en 2 weeks after<br /><br>intervention?</p><br>