MORPHINE SPARING EFFECT OF INTERMITTENT VERSUS CONTINUOUS INTRAVENOUS INFUSION OF NEFOPAM IN PATIENTS AFTER TOTAL KNEE ARTHROPLASTY
Phase 4
Recruiting
- Conditions
- unilateral primary gonarthrosisosteoarthritis, total knee arthroplasty, Nefopam, morphine sparing effect
- Registration Number
- TCTR202103160010
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 144
Inclusion Criteria
1. age 18 years and above
2. undergoing primary unilateral total knee arthroplasty
3. weight at least 45 kilograms
Exclusion Criteria
1. patients with seizure or have history of seizure
2. patients with benign prostatic hypertrophy or abnormality of urinary tract
3. close angle glaucoma
4. cardiovascular and cerebrovascular disease
5. creatinine clearance less than 30 ml/min
6. impaired hepatic function
7. have current medications in SSRI, SNRI and TCA
8. psychiatric patients
9. have underlying disease involve abnormality of spine and hip
10. intra-operative complications
11. denied morphine use
12. allergic to any medications in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method morphine consumption at 48 hours milligrams
- Secondary Outcome Measures
Name Time Method pain score at rest every 4 hours numeric rating scale,adveres drug reactions during study peroid nurse record