Brain Exercises for Synaptic Plasticity
- Conditions
- Cognitive Change
- Registration Number
- NCT03058055
- Lead Sponsor
- University of Kentucky
- Brief Summary
The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts over an 8 week period, including active reading vs. origami study arms and a placebo group without structured cognitive intervention.
- Detailed Description
This is a randomized, placebo controlled study investigating the practical implementation and conduct of two cognitive interventions in non-demented subjects. Subjects will be randomized 1:1:1 into three groups including: 1) a Book club that includes weekly one hour meetings and daily reading assignments, 2) Origami lessons (one hour/week) with daily take home Origami activities to complete, and 3) a placebo group with unstructured lifestyle activities (normal lifestyle activities without restraint).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
- Non demented community dwelling elders
- Unable to perform the reading or origami tasks for any reason
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method FCSRT 8 weeks The Free and Cued Selective Reminding Test (FCSRT) measures memory function.
MOCA 8 weeks The Montreal Cognitive Assessment (MOCA) measures general cognitive function
- Secondary Outcome Measures
Name Time Method Evoked Related Potential 8 weeks Evoked Related Potential P300 using the Bluegrass memory task
Electroencephalogram 8 weeks resting state electroencephalogram pattern
Adherence to protocol 8 weeks Objective measures of weekly time devoted to cognitive training activities
Trial Locations
- Locations (1)
Sander's Brown Center on Aging
🇺🇸Lexington, Kentucky, United States
Sander's Brown Center on Aging🇺🇸Lexington, Kentucky, United States