Brain Exercises for Synaptic Plasticity: the BEST Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cognitive Change
- Sponsor
- University of Kentucky
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- FCSRT
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts over an 8 week period, including active reading vs. origami study arms and a placebo group without structured cognitive intervention.
Detailed Description
This is a randomized, placebo controlled study investigating the practical implementation and conduct of two cognitive interventions in non-demented subjects. Subjects will be randomized 1:1:1 into three groups including: 1) a Book club that includes weekly one hour meetings and daily reading assignments, 2) Origami lessons (one hour/week) with daily take home Origami activities to complete, and 3) a placebo group with unstructured lifestyle activities (normal lifestyle activities without restraint).
Investigators
Gregory Jicha, 323-5550
M.D., Ph.D., Professor
University of Kentucky
Eligibility Criteria
Inclusion Criteria
- •Non demented community dwelling elders
Exclusion Criteria
- •Unable to perform the reading or origami tasks for any reason
Outcomes
Primary Outcomes
FCSRT
Time Frame: 8 weeks
The Free and Cued Selective Reminding Test (FCSRT) measures memory function.
MOCA
Time Frame: 8 weeks
The Montreal Cognitive Assessment (MOCA) measures general cognitive function
Secondary Outcomes
- Electroencephalogram(8 weeks)
- Evoked Related Potential(8 weeks)
- Adherence to protocol(8 weeks)