Exercise-induced left ventricular diastolic dysfunction in COPD patients with a symptomatic limitation to exercise

Recruiting

• Conditions: chronic obstructive pulmonary disease; emfysema or chronic bronchitis; 10019280; 10037454

• Registration Number: NL-OMON39266
• Lead Sponsor: Onze Lieve Vrouwe Gasthuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

- COPD patients classified according to the GOLD staging system and the criteria of the BODE index
- Informed consent
- > 18 years of age
- Male and female
- Patients able to perform a cycling test

Exclusion Criteria

- Age <= 18 years of age
- Pregnancy
- Patients not able to perform a cycling test
- Patients with clinical evidence of significant cardiovascular disease (including coronary artery disease, history of myocardial infarcation, significant valvular disease, cardiomyopathy, arterial hypertension, echocardiographic presence of left ventricular systolic dysfunction)
- Patients with atrial fibrillation.
- Patients on cardiac medication (ACE inhibitors, beta-blockers, AT-II antagonists, Calcium channel blockers)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>•Exercise-induced LV-DD; defined by E/E* > 15 during stress echocardiography.</p><br>