NCT00550121已完成不适用
Does Ascorbic Acid Reduce Sympathoexcitation in CHF?
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 试验地点
- 1
- 主要终点
- change in central sympathetic output after vitamin C vs. placebo
研究概览
简要总结
In CHF central sympathetic activity is increased. ROS formation seems to play a role in this process. This study analyzes the effect of vitamin C as an antioxidant on central sympathetic activity in CHF
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Heart failure of at least New York Heart Association (NYHA) class II
- •Left ventricular ejection fraction (LVEF) <= 40%
- •Age 20-80 years
排除标准
- •Necessity of short-term PCI, CABG or heart transplantation,
- •Chronic disease of the autonomic nervous system,
- •diabetes mellitus,
- •use of tricyclic antidepressant drugs and/or a-adrenergic receptor antagonists.
研究组 & 干预措施
1
Experimental
干预措施: vitamin C (Drug)
2
Placebo Comparator
干预措施: placebo (Drug)
结局指标
主要结局
change in central sympathetic output after vitamin C vs. placebo
次要结局
未报告次要终点
研究者
研究点 (1)
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