A clinical trial to compare and study the effects of pantoprazole versus placebo in patients of acute caustic ingestio
Phase 2
- Conditions
- Health Condition 1: T287- Corrosion of other parts of alimentary tract
- Registration Number
- CTRI/2024/04/065100
- Lead Sponsor
- Department of Emergency Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. All consecutive patients with history of acute corrosive ingestion(within 48 hours of corrosive ingestion)
2. Age = 18 years
3. Valid consent given by the patient for the study
Exclusion Criteria
1.Hemodynamically unstable patient
2.Patients who have received Cardio Pulmonary Resuscitation
3.Patients who need Endotracheal intubation and mechanical ventilation
4.Patients who are not conscious
5.History of corrosive ingestion of greater than 2 days
6.Age less than 18 years
7.Patients who refused to give valid consent for the study
8.Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the efficacy of proton pump inhibitor (pantoprazole) versus placebo in the change in endoscopic grading in both intervention and control group after 3 daysTimepoint: To compare the efficacy of proton pump inhibitor (pantoprazole) versus placebo in the change in endoscopic grading in both intervention and control group after 3 days
- Secondary Outcome Measures
Name Time Method To compare possible complications like infection, diarrhea, sepsis, stridor, hoarseness, upper gastrointestinal bleed, acute respiratory distress syndrome, acute kidney injury, perforation, peritonitis and mediastinitis in both intervention and control group.Timepoint: Upto 6 weeks to understand the outcome in terms of esophageal stricture formation and complications