Efficacy and Safety of Magnesium Sulfate Added to Local Anesthetic in TAP Block for Postoperative Analgesia Following Total Abdominal Hysterectomy.
试验速览
- 阶段
- 2 期
- 入组人数
- 60
- 主要终点
- total postoperative morphine consumption
研究概览
简要总结
Major abdominal surgeries are associated with severe abdominal pain, which can affect respiratory and cardiac functions, if insufficiently managed. This increases the incidence of post-operative morbidity.
The objective of this study was to detect the efficacy and safety of magnesium sulphate as an adjuvant to the analgesia offered by local anesthetic in ultrasound guided TAP block in patients undergoing total abdominal hysterectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •weight: 50- 85 kg.
- •ASA score: I-III
- •scheduled for total abdominal hysterectomy
排除标准
- •history of relevant drug allergy.
- •coagulation disorders.
- •opioid dependence.
- •psychiatric illnesses that would interfere with perception and assessment of pain.
研究组 & 干预措施
Magnesium group
patients received ultrasound guided TAP block with 20 mL of 0.25% bupivacaine plus 2 mL magnesium sulphate 10% (200 mg), on each side of the abdominal wall.
干预措施: Magnesium Sulfate (Drug)
control group
patients received ultrasound guided TAP block with 20 mL of 0.25% bupivacaine on each side of the abdominal wall.
干预措施: Bupivacaine (Drug)
结局指标
主要结局
total postoperative morphine consumption
时间窗: postoperative 24 hours
total amount of rescue morphine consumption in the first 24 hours postoperatively
次要结局
- postoperative pain(postoperative 24 hours)
- first request of rescue analgesia(postoperative 24 hours)
- side effects(postoperative 24 hours)
研究者
Ahmad Mohammad Abd El-Rahman
lecturer of anesthesia,ICU, and pain management
Assiut University