Efficacy and Safety of Magnesium Sulfate Added to Local Anesthetic in TAP Block for Postoperative Analgesia Following Total Abdominal Hysterectomy.
Overview
- Phase
- Phase 2
- Intervention
- Magnesium Sulfate
- Conditions
- Postoperative Pain
- Sponsor
- Assiut University
- Enrollment
- 60
- Primary Endpoint
- total postoperative morphine consumption
- Last Updated
- 9 years ago
Overview
Brief Summary
Major abdominal surgeries are associated with severe abdominal pain, which can affect respiratory and cardiac functions, if insufficiently managed. This increases the incidence of post-operative morbidity.
The objective of this study was to detect the efficacy and safety of magnesium sulphate as an adjuvant to the analgesia offered by local anesthetic in ultrasound guided TAP block in patients undergoing total abdominal hysterectomy.
Investigators
Ahmad Mohammad Abd El-Rahman
lecturer of anesthesia,ICU, and pain management
Assiut University
Eligibility Criteria
Inclusion Criteria
- •weight: 50- 85 kg.
- •ASA score: I-III
- •scheduled for total abdominal hysterectomy
Exclusion Criteria
- •history of relevant drug allergy.
- •coagulation disorders.
- •opioid dependence.
- •psychiatric illnesses that would interfere with perception and assessment of pain.
Arms & Interventions
Magnesium group
patients received ultrasound guided TAP block with 20 mL of 0.25% bupivacaine plus 2 mL magnesium sulphate 10% (200 mg), on each side of the abdominal wall.
Intervention: Magnesium Sulfate
control group
patients received ultrasound guided TAP block with 20 mL of 0.25% bupivacaine on each side of the abdominal wall.
Intervention: Bupivacaine
Outcomes
Primary Outcomes
total postoperative morphine consumption
Time Frame: postoperative 24 hours
total amount of rescue morphine consumption in the first 24 hours postoperatively
Secondary Outcomes
- postoperative pain(postoperative 24 hours)
- first request of rescue analgesia(postoperative 24 hours)
- side effects(postoperative 24 hours)