Effects of Continuous Femoral Nerve Block Versus Single-Injection Femoral Nerve Block With Intravenous Patient Controlled Analgesia Versus Intravenous Patient Controlled Analgesia on Knee Pain and Function After Total Knee Replacement
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain
- Sponsor
- Tan Tock Seng Hospital
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Incidence of patients with significant pain on movement on day 1 post surgery
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to compare the effectiveness of three analgesia techniques on pain relief and functional recovery after knee replacement: continuous femoral nerve block vs single-injection femoral nerve block with intravenous patient controlled analgesia vs intravenous patient controlled analgesia.
Detailed Description
Primary Outcome Measures: * Incidence of patients with significant pain on movement on day 1 post surgery * Range of knee flexion Secondary Outcome Measures: * Pain intensity (rest/movement) * Functional recovery * Knee Injury and Osteoarthritis Score * Side effects/ Adverse outcomes * SF12 Quality of Life Questionnaire * Length of stay
Investigators
Chan Ee Yuee
Dr
Tan Tock Seng Hospital
Eligibility Criteria
Inclusion Criteria
- •40 years and above
- •Osteoarthritis
- •Primary unilateral total knee replacement
- •No other lower extremity joint disease
- •ASA I-III
- •Body mass index \< 35
- •No severe cardiac or pulmonary diseases
- •No chronic narcotic therapy or illicit drug use
- •Mentally competent to understand study procedures and use of pain scales
- •Able to provide informed consent
Exclusion Criteria
- •Any cause for knee replacement other than osteoarthritis
- •Total knee revision
- •Any contraindication for femoral block
- •Abnormal coagulation studies
- •Thrombocytopenia less than 100,000/cc
- •Known hepatic or renal insufficiency
- •Neurological disease involving lower extremities
- •Major surgery during the last 2 weeks pre-operatively
- •History of allergy to study medications
- •History of post-operative bleeding over 2000 cc/24 hours
Outcomes
Primary Outcomes
Incidence of patients with significant pain on movement on day 1 post surgery
Time Frame: Post op day 1
Secondary Outcomes
- Functional recovery(During hospitalization, week 2, week 12)