To study the development of mitochondrial dysfunction in septic Intensive Care Unit patients with respect to the hypermetabolic inflammatory status
Not Applicable
Completed
- Conditions
- <p>Sepsis, mitochondrial disfunction, hypermetabolic inflammatory status</p>Septic shock10021879
- Registration Number
- NL-OMON20834
- Lead Sponsor
- Wageningen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
- Sepsis originated from abdomen or respiratory system
- Admission to the ICU of Gelderse Vallei Hospital
Exclusion Criteria
• Patients younger than 18 years
• Patients with a haemoglobin level lower than 5,5 mmol/lL*
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Mitochondrial capacity in PBMCs measured via functional respirometry.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameters are (a) parameters of hypermetabolic inflammatory status (concentrations of hormones, nutrients and cytokines in the plasma), (b) mitochondrial dynamics and autophagy and (c) data from medical records.</p><br>