The Possible Implication of Mitochondrial Dysfunction in Peripheral Blood Mononuclear Cells of Trigeminal Neuralgia Patients with or Without Coenzyme Q10 Therapy

Phase 4

Recruiting

• Conditions: - Trigeminal neuralgia (TN) is a chronic painful condition involving the trigeminal nerve- Can be characterized by recurrent unilateral brief electric shock- like pains, abrupt in onset and terminatio; Trigeminal neuralgia; Neuropathic pain

• Registration Number: TCTR20171009002
• Lead Sponsor: Thailand Research Fund Grants

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-10-09
• Study Completion: 2017-12-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

-Adult (≥ 18 years old)
-Present with features of TN, based on current guidelines of the Headache Classification Committee of the International Headache Society (IHS)

Exclusion Criteria

-Patients with painful trigeminal neuropathy (e.g. due to the growth of organic lesions or tumors)
-Acute infectious disease within the previous three weeks
-Past or present neurological, psychiatric, metabolic, cardiovascular, muscular, or chronic inflammatory disease
-Smoking habits or alcohol consumption of more than 40 g/day
-Medical conditions that required treatment with glucocorticoids, analgesics, or antidepressant drugs
-Pregnancy or current breastfeeding.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
oxidative stress levels 24 h Reactive oxygen species (ROS) production in PBMCs by flow cytometry measurement

Secondary Outcome Measures

Name	Time	Method
pro-inflammatory cytokines including TNF-α, IL-1β and IL-18 mRNA expression 24 h SYBR Green quantitative real-time PCR (qRT-PCR)