Mitochondrial dysfunction in PBMCs is associated with the severity of liver fibrosis in patients after the Fontan operatio

Completed

• Conditions: Fontan patients; Fontan operation; mitochondrial function; liver biopsy; liver fibrosis; cirrhosis

• Registration Number: TCTR20230601009
• Lead Sponsor: The National Research Council of Thailand

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-12-30
• Study Start: 2023-06-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

Fontan patients without known underlying liver diseases and age more than 15 years
- Give inform consent

Exclusion Criteria

- Known case underlying liver diseases

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mitochondrial function 1 day Mitochondrial level

Secondary Outcome Measures

Name	Time	Method
Echocardiography 1 day Systemic ventricular function,Computerized tomography scan of upper abdomen 1 day Liver parenchymal and nodular abnormalities,Ultrasound of upper abdomen 1 day Liver parenchymal and nodular abnormalities,Magnetic resonance imaging of upper abdomen 1 day Liver parenchymal and nodular abnormalities,Magnetic resonance elastography 1 day Liver parenchymal and nodular abnormalities,Ultrasound liver elastography 1 day Liver parenchymal and nodular abnormalities,Cardiac catheterization 1 day Hemodynamic study,Stool gut microbiota 1 day microbiota,Holter 1 day Arrhythmia