Mitochondrial dysfunction in genetic parkinsonism: what muscles can tell us about the brai

• Conditions: Parkinson's disease; 10028037

• Registration Number: NL-OMON31198
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Patients with a proven autosomal recessive Parkinson's disease carrying the parkin mutation.

Exclusion Criteria

age under 18 years
dementia
use of anticoagulants

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Histology:<br /><br>1. presence and number of Cox-negative fibres<br /><br>2. morphology of the mitochondriae<br /><br><br /><br>Mitochondrial:<br /><br>1. substrate oxidations<br /><br>2. ATP metabolism<br /><br>3. enzyme activity (complex I to V)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>No secundary outcome parameters</p><br>