The effect of the treatment of periodontitis on rheumatoid arthritis disease activity
- Conditions
- Condition 1: Periodontitis. Condition 2: Rheumatoid arthritis.Chronic periodontitisRheumatoid arthritis, unspecified
- Registration Number
- IRCT2015122512823N3
- Lead Sponsor
- Semnan University of Medical Sciences
- Brief Summary
Background: Many patients with rheumatoid arthritis (RA), which is one of the most common inflammatory diseases, at the same time, suffer from periodontitis. Since some studies have shown a common biochemical link between the synchronicity of these two diseases, we decided to investigate the effects of periodontal therapy on disease activity in RA.<br /> Materials and Methods: In this quasi-experimental study, 30 patients with simultaneous RA and periodontitis referred to the rheumatology clinic in Semnan from March 2014 to February 2016 were selected through census method. Disease activity score uses 28 joint counts (DAS28) questionnaires were completed and referred to executive dentist of the project. Patients with confirmed periodontitis were received treatments including non-surgical scaling, Root planning, systemic antibiotics (10-day period, capsules of amoxicillin and metronidazole, 3 per day) and chlorhexidine as well as oral health education. Then, at days 45 and 90 after treatment, the patients were visited by a rheumatologist and DAS28 questionnaire was again completed. ESR and CRP of each visit were evaluated in reference laboratories at Semnan University of Medical Sciences.<br /> Results: the evaluation of 30 patients with mean age of 50.2±10.62 years (80% female) showed that the difference in the level of disease activity between baseline versus 45 days later (5.18±0.092 vs 4.02±1.22, p
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
18 years and older; diagnosis of RA at least one year ago; disease activity score between 3.2 and 5.1; having at least six natural teeth; the patient be educable; having gingivitis with mild to moderate degree.
The exclusion criteria were: risk of infection; serious liver or kidney diseases; chronic infectious disease that needs to frequent use of antibiotics; uncontrolled diabetes; taking anti-thrombotic and biologic therapy; sensitivity to chlorhexidine gluconate (oral rinse); contraindication of amoxicillin and metronidazole; severe oral problems which requiring immediate surgery; pregnancy, breast-feeding or if want to get pregnant during the study period; any febrile or chronic diseases.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rheumatoid arthritis activity. Timepoint: Before initiation of interventions, 45 and 90 days after intervention. Method of measurement: DAS-28 questionnaire.
- Secondary Outcome Measures
Name Time Method Erythrocyte Sedimentation Rate. Timepoint: Before initiation of interventions, 45 and 90 days after intervention. Method of measurement: Laboratory test.;C- reactive protein. Timepoint: Before initiation of interventions, 45 and 90 days after intervention. Method of measurement: Laboratory test.