Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization

Not yet recruiting

• Conditions: Rheumatoid Arthritis; Periodontitis

• Registration Number: NCT06603207
• Lead Sponsor: Zhibin Xu

Brief Summary

This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.

Detailed Description

The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.

Study Timeline

• Status Verified: 2024-09
• Study First Submitted: 2024-09-17
• Study First Submitted QC: 2024-09-17
• Last Update Submitted: 2024-09-17
• Study First Posted: 2024-09-19
• Last Update Posted: 2024-09-19
• Study Start: 2024-10-01
• Primary Completion: 2024-11-01
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 220000

Inclusion Criteria

• Participants included in the genome-wide association study (GWAS) database.
• Subjects with available genotypic data relevant to rheumatoid arthritis and periodontitis.

Exclusion Criteria

• Individuals without complete genotypic data or those with missing critical phenotypic information.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Causal Association Between Rheumatoid Arthritis and Periodontitis	Data collected from 2023 to 2024.	This study uses Mendelian randomization to evaluate the causal relationship between rheumatoid arthritis (RA) and periodontitis in the East Asian population. The analysis utilizes genome-wide association study (GWAS) data, employing inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess the genetic relationship and the risk contribution of RA to the development of periodontitis.

Secondary Outcome Measures

Name	Time	Method
Analysis of Genetic Pleiotropy and Confounders	2023 to 2024	Evaluation of the presence of genetic pleiotropy and its potential effect on the association between rheumatoid arthritis and periodontitis.