Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? A cross-over clinical trial

Completed

• Conditions: gum disease; periodontal disease; 10001708; 10004018

• Registration Number: NL-OMON36017
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 70

Inclusion Criteria

RA patients
1. Fulfilling the American College of Rheumatology classification criteria for RA (1987)
2. Age > 18 years
3. Fulfilling the classification criteria of periodontal diseases for generalized severe chronic periodontitis according
to the 1999 International Workshop for Classification of Periodontal Diseases and Conditions

Exclusion Criteria

1. Infection or inflammation other than periodontitis or RA
2 Present malignancy
3. Other conditions which influence the immune system:, diabetes, active thyroid disease, myocardial infarction,
stroke or recanalisation of the femoral arteries for claudication <6 months prior to the study
4. Pregnancy including a 6-months post-partem period as well as breastfeeding
5. Malnutrition
6. Alcoholism and drug abuse
7. Pharmacological interference: use of corticosteroids >10mg/dag, antibiotic use during 3 months prior to the
study, allergy to amoxicillin or metronidazole
8. Edentulism

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Disease Activity Score 28 joint count (DAS28)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Periodontal Inflamed Surface Area (PISA)<br /><br>ACPA titer<br /><br>Leucocyte count, CRP and ESR.<br /><br>Presence of P. gingivalis in microbial plaque</p><br>