Periodontitis and Rreumatoid arthritis- association, dual treatment and resolution study
Completed
- Conditions
- destructive inflammation of periodontal ttisuesperiodontitis100038161000401810013361
- Registration Number
- NL-OMON43308
- Lead Sponsor
- reumatologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
(N<=20 per group)
1. early, untreated rheumatoid arthritis (RA) patients with peridontitis (PD)
2. early, untreated RA patients without PD
3. matched PD patients as controls
4. RA risk individuals with PD
5. RA risk individuals without PD.
Exclusion Criteria
active infectious or other inflammatory disease
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>the effect of resolvin E1 on T helper 17 activation and pro-inflammatory<br /><br>cytokines in gingival, blood and synovial tissue from RA patients and on<br /><br>gingival tissue and blood of patients at risk for RA. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Presence, isotype and fine specificity of ACPA, arginin control antibodies and<br /><br>anti-P.gingivalis antibodies, bacterial cell numbers and products and key<br /><br>inflammatory cytokines and chemokines in gingival tissue and synovial tissue of<br /><br>patients with PD and RA and patients with PD at risk for RA. </p><br>