Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? Presence of Anti Citrullinated Protein Antibodies (ACPAs) in periodontitis.

Completed

• Conditions: gum disease; 10004018; periodontal disease; 10003816

• Registration Number: NL-OMON36598
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

1. Fulfilling the classification criteria of periodontal diseases for generalized severe periodontitis according to the 1999 International Workshop for Classification of Periodontal Diseases and Conditions
2. Age > 18 years

Exclusion Criteria

According to the SENIEUR protocol (1984)
1. Infection or inflammation other than periodontitis.
2. Malignancy, past or present
3. Other conditions which influence the immune system: RA, diabetes, active thyroid disease
myocardial infarction, stroke or recanalisation of the femoral arteries for claudication <6 months prior to the study
4. Pregnancy including a 6-months post-partem period as well as breastfeeding
5. Malnutrition
6. Alcoholism and drug abuse
7. Use of corticosteroids >10mg/day, antibiotic use during 3 months prior to the study
8. Edentulism

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>ACPA titer</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Periodontal inflamed surface area (PISA), presence of P. gingivalis, and<br /><br>development of clinical symptoms of RA.</p><br>