Bactericidal Permeability Protein Inhibitor and Interleukin-1beta Levels After Non-surgical Periodontal Treatment

Not Applicable

Completed

• Conditions: Periodontitis
• Interventions: Procedure: Non-surgical periodontal treatment

• Registration Number: NCT06354504
• Lead Sponsor: Akdeniz University

Brief Summary

The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival crevicular fluid (GCF) levels of bactericidal/permeability-increasing protein (BPI) and interleukin-1beta (IL-1ß).

Detailed Description

Bactericidal/permeability-increasing proteins (BPI) specific and powerful effect against Gram negative bacteria and their LPSs is completely observable in biological fluids such as plasma, serum, and whole blood.

Objective: It is the evaluation of periodontal disease effect of BPI and interleukin-1 beta (IL-1 β) levels in gingival fluid before and after non-surgical periodontal treatment (NSPT)in patients with periodontal disease.

Method: Thirty systemically healthy and non-smoking individuals with periodontitis were included in the study. Before NSPT, the clinical parameters of plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAS), bleeding on probing (BOP) were measured. The gingival fluid samples were taken using the paper strip method. The same procedures were repeated at 6 weeks and 6 months after non-surgical periodontal treatment. ELISA method was used for the analysis of the samples

Study Timeline

• Study Start: 2019-11-19
• Primary Completion: 2020-09-20
• Study Completion: 2020-09-20
• Study First Submitted: 2024-03-07
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-03
• Last Update Submitted: 2024-04-03
• Study First Posted: 2024-04-09
• Last Update Posted: 2024-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

Smoking,

• use of alcohol; pregnancy or lactation; intake ofantibiotics, steroidal or non-steroidal anti-inflammatory drugs within the last 6 months
• having received periodontal treatment within the last 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Healty	Non-surgical periodontal treatment	Non-surgical periodontal treatment

Primary Outcome Measures

Name	Time	Method
Gingival crevicular fluid Bactericidal/permeability-increasing proteins levels	through study completion, an average of 1 year	Gingival Crevicular Fluid Bactericidal Permeability Increasing Protein levels in periodonitis patients after Non-surgical periodontal treatment

Secondary Outcome Measures

Name	Time	Method
Gingival crevicular fluid interleukin-1Beta levels	through study completion, an average of 1 year	Gingival Crevicular Fluid IL-1β in periodonitis patients after Non-surgical periodontal treatment

Trial Locations

Locations (2)

Akdeniz Üniversitesi Diş Hekimliği Fakültesi; 🇹🇷 Antalya, Turkey

Akdeniz Üniversity; 🇹🇷 Antalya, Turkey