Effect of step aerobic exercise in patients with asthma

Phase 3

Recruiting

• Conditions: Asthma; Aerobic exercise; Oxidative stress; Inflammation; Physical fitness

• Registration Number: TCTR20240427009
• Lead Sponsor: Faculty of Medicine, Khon Kaen University, Thailand

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-27
• Last Update Posted: 19 August 2024
• Study Completion: 2024-09-27

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Women or men are diagnosed with asthma according to GINA guidelines
2. Age 18-65 years
3. Non regular exercise (less than 3 times/week and less than 30 min/day)
4. Participants receive stable dose of asthmatic drug at least 1 month before participation of the study.

Exclusion Criteria

1. There are other respiratory diseases such as chronic obstructive pulmonary disease and respiratory tract infection.
2. There are exacerbation within 1 month before participation of the study.
3. Congestive heart failure, angina pectoris
4. There are abnormal of muscle and bone affecting movement of knee and ankle.
5. Presence of neuromuscular conditions interfering with the ability to perform step aerobic exercise such as herniated disc and muscle weakness

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Asthma control Pre, intermediate, and post exercise training Asthma control questionnaire

Secondary Outcome Measures

Name	Time	Method
Oxidative stress Pre, intermediate, and post exercise training Malondialdehyde and catalase,Airway inflammation Pre, intermediate, and post exercise training Fractional exhaled nitric oxide,Systemic inflammation Pre, intermediate, and post exercise training High sensitivity C-reactive protein, IL5,Pulmonary function Pre, intermediate, and post exercise training Lung volumes, flow rates, and respiratory muscle strength,Physical performance Pre, intermediate, and post exercise training Timed up and go test, single leg stance test, thirty-second chair stand test, walking speed,Exercise capacity Pre, intermediate, and post exercise training Assessment of distance walked over 6 minutes