Does the time between the production of semen and Intra-Uterine Insemination has an impact on pregnancy rates? A prospective randomized clinical trial.

Recruiting

• Conditions: Subfertility

• Registration Number: NL-OMON25500
• Lead Sponsor: /a

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 254

Inclusion Criteria

Patients who start their first IUI treatment. All subsequent cycles fall within this study. Only patients who undergo six IUI cycles, three times in a natural cycle and three times in a stimulated cycle, fall within this study. Patients who start a new IUI treatment after an ongoing pregnancy. Both IUI performed in a natural cycle and stimulated cycles fall within this study. Patients with well-adjusted, non-endocrine hormonal pathology fall within this study.

Exclusion Criteria

Patients who have IUI with donorsemen. Patients in which the semen was obtained in a different way than masturbation (bladder irrigation, electrical stimulation). Patients who have less than 0.5 million progressive motile sperm left over after work-up of semen. Patients with polycystic ovarian syndrome (PCOS). Patients with imminent ovarian failure (basal FSH> 10 IU / l).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ongoing pregnancy rate per patient couple (positive fetal cardiac activity 10 weeks after IUI).

Secondary Outcome Measures

Name	Time	Method
Clinical pregnancy rate per IUI cycle (HCG> 50 IU /l at 16 days after IUI). Ongoing pregnancy rate per IUI cycle (positive fetal cardiac activity 10 weeks after IUI). Percentage multiple pregnancies Percentage biochemical pregnancies and abortions Percentage/number of live births.