Synovial activation In Post-traumatic arthritis Study
Recruiting
- Conditions
- arthrosisosteoarthritis10023213
- Registration Number
- NL-OMON48619
- Lead Sponsor
- reumatologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1. 20 patients with a recent anterior cruciate ligament injury
2. 20 patients with a recent meniscal injury
3. 20 patients with post-traumatic osteoartrhritis.
Group 1
18 years or older
Recently (<2 months) suffered a cruciate ligament injury of the index knee.
a swollen joint
Group 2
18 years or older
Recently (<2 months) suffered a meniscal injury of the index knee.
a swollen joint
Group 3
18 years or older
Knee OA according to the clinical ACR criteria for knee OA
Suffered a knee injury (e.g. ligament rupture with subsequent reconstruction)
before development of OA in the index knee
a swollen joint
Exclusion Criteria
Patients with an active inflammatory or infectious co-morbid disease
Knee prosthesis
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Baseline concentrations and change in crystal concentration before and after<br /><br>exercise in post-traumatic arthritis, post-traumatic OA versus non<br /><br>post-traumatic OA</p><br>
- Secondary Outcome Measures
Name Time Method <p>Correlation between crystals in blood and synovial fluid with inflammatory<br /><br>mediators and leucocyte activation</p><br>