Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study
Not Applicable
Completed
- Conditions
- Wheat Allergy
- Interventions
- Other: Commercial extract and in-house wheat extract
- Registration Number
- NCT01070368
- Lead Sponsor
- Mahidol University
- Brief Summary
Nowadays, commercial wheat extract is widely accessible, and is used for skin prick test for wheat allergy. However, commercial wheat extracted for skin prick test have less precise test result compared to extract from omega-5 gliadin, which is one of the major allergen with immediate wheat allergy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- A patient with the age of 1-15 year old
- A history of symptoms that suspected of type 1 hypersensitivity (eg. Urticaria, angioedema, wheezing, anaphylaxis) occur within 4 hours after wheat ingestion.
- Patients attend in allergy clinic, pediatric department, Siriraj hospital since 2007-2012
Exclusion Criteria
- First sign and symptom happens more than 4 hours since wheat ingestion
- Have underlying disease such as heart disease, epilepsy etc.
- Have contraindication for performed skin prick test
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Food challenge, skin test Commercial extract and in-house wheat extract Skin test by two extract commercial, and in-house extract. and open challenge with wheat (except in patient with history of wheat anaphylaxis: assume as challenge positive)
- Primary Outcome Measures
Name Time Method correlation skin test result and food challenge result 3 year
- Secondary Outcome Measures
Name Time Method comparison of skin test result and specific IgE to challenge result 3 year
Trial Locations
- Locations (1)
Pediatric department, Faculty of medicine Siriraj hospital, Mahidol university
🇹ðŸ‡Bangkok, Thailand