A Multicenter, Randomized, Double-Blind, Placebo Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Ulcerative Colitis
- Conditions
- Ulcerative Colitis (UC)
- Interventions
- Registration Number
- NCT03398148
- Lead Sponsor
- AbbVie
- Brief Summary
The objectives of Sub-Study 1 are to evaluate the efficacy, safety, and pharmacokinetics of risankizumab as induction treatment in subjects with moderately to severely active ulcerative colitis (UC), and to identify the appropriate induction dose of risankizumab for further evaluation in Sub-Study 2.
The objective of Sub-Study 2 is to evaluate the efficacy and safety of risankizumab compared to placebo in inducing clinical remission in subjects with moderately to severely active UC.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1558
- Male or female aged >=18 to <= 80 years at the Baseline Visit. Where locally permissible, subjects 16 to < 18 years of age who meet the definition of Tanner stage 5 for development at the Baseline Visit.
- Confirmed diagnosis of ulcerative colitis (UC) for at least 3 months prior to Baseline.
- Active UC as assessed by Adapted Mayo Score and Endoscopic Subscore.
- Demonstrated intolerance or inadequate response to conventional therapy and tofacitinib (not a biologic) and one or more biologic therapies.
- Females must be postmenopausal for more than 1 year or surgically sterile or practicing specific forms of birth control.
- Participant with a current diagnosis of Crohn's disease (CD), inflammatory bowel disease-unclassified (IBD-U) or a history of radiation colitis or ischemic colitis.
- Participant receiving prohibited medications and treatment.
- Extent of inflammatory disease limited to the rectum as assessed by screening endoscopy.
- Participant with currently known complications of UC (e.g., megacolon).
- No known active Coronavirus Disease - 2019 (COVID-19) infection.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Substudy 1, Induction 1: Double-blind Risankizumab Dose 1 risankizumab IV Participants randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion. Substudy 1, Induction 1: Double-blind Risankizumab Dose 2 risankizumab IV Participants randomized to receive risankizumab dose 2 administered by intravenous (IV) infusion. Substudy 1, Induction 1: Double-blind Risankizumab Dose 3 risankizumab IV Participants randomized to receive risankizumab dose 3 administered by intravenous (IV) infusion. Substudy 1, Induction 1: Open-label Risankizumab Dose 1 risankizumab IV Participants receive risankizumab dose 1 administered by intravenous (IV) infusion. Substudy 1, Induction 2: Double-blind Risankizumab Dose 1(a) risankizumab IV Participants who received placebo with inadequate response in Induction 1 receive risankizumab dose 1 administered by intravenous (IV) infusion in Induction 2. Substudy 2, Induction 1: Double-blind Risankizumab Dose 1 risankizumab IV Participants randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion. Substudy 2, Induction 1: Double-blind Placebo risankizumab IV Participants randomized to receive placebo for risankizumab administered by intravenous (IV) infusion. Substudy 2, Induction 2: Double-blind Risankizumab Dose 1(a) risankizumab IV Participants who received placebo with inadequate response in Induction 1 randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion in Induction 2. Substudy 2, Induction 2: Double-blind Risankizumab Dose 2 risankizumab SC Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab dose 2 administered by subcutaneous (SC) injection in Induction 2. Substudy 2, Induction 2: Double-blind Risankizumab Dose 3 risankizumab SC Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab dose 3 administered by subcutaneous (SC) injection in Induction 2. Substudy 1, Induction 2: Double-blind Risankizumab Dose 3 risankizumab SC Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab dose 3 administered by subcutaneous (SC) injection in Induction 2. Substudy 2, Induction 2: Double-blind Risankizumab Dose 1(b) risankizumab IV Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion in Induction 2. Substudy 2, Induction 1: Double-blind Placebo placebo for risankizumab Participants randomized to receive placebo for risankizumab administered by intravenous (IV) infusion. Substudy 1, Induction 1: Double-blind Placebo placebo for risankizumab Participants randomized to receive placebo for risankizumab administered by intravenous (IV) infusion. Substudy 1, Induction 2: Double-blind Risankizumab Dose 1(b) risankizumab IV Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion in Induction 2. Substudy 1, Induction 2: Double-blind Risankizumab Dose 2 risankizumab SC Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab dose 2 administered by subcutaneous (SC) injection in Induction 2.
- Primary Outcome Measures
Name Time Method Sub-Study 1 and Sub-Study 2: Percentage of Participants Achieving Clinical Remission per Adapted Mayo Score Week 12 Clinical remission per adapted Mayo Score.
- Secondary Outcome Measures
Name Time Method Sub-Study 2: Percentage of Participants Achieving Clinical Response per Partial Adapted Mayo Score at Week 4 Week 4 Clinical response per Partial Adapted Mayo Score (without endoscopy).
Sub-Study 1: Percentage of Participants Achieving Histologic Endoscopic Mucosal Remission (HEMR) Week 12 Mucosal healing defined as endoscopic and histologic remission.
Sub-Study 1: Percentage of Participants Achieving Endoscopic Improvement Week 12 Endoscopic improvement per endoscopy subscore.
Sub-Study 1: Percentage of Participants Achieving Clinical Remission per Full Mayo Score in Participants with a Full Mayo Score of 6 to 12 at Baseline Week 12 Clinical remission per Full Mayo Score.
Sub-Study 1: Percentage of Participants with Hospitalization Through Week 12 Participants with an event that results in admission to the hospital.
Sub-Study 2: Percentage of Participants Achieving Endoscopic Remission Week 12 Endoscopic remission per endoscopy subscore.
Sub-Study 2: Change in Inflammatory Bowel Disease Questionnaire (IBDQ) total score Baseline to Week 12 The IBDQ is used to assess the quality of life of patients with inflammatory bowel disease.
Sub-Study 2: Change in Number of Fecal Incontinence Episodes per Week Baseline to Week 12 Change in number of fecal incontinence episodes per week.
Sub-Study 1: Percentage of Participants Achieving Clinical Response per Partial Adapted Mayo Score Week 4 Clinical response per Partial Adapted Mayo Score (without endoscopy).
Sub-Study 2: Percentage of Participants Achieving No Bowel Urgency Week 12 Percentage of participants who reported no bowel urgency.
Sub-Study 2: Percentage of Participants Achieving Histologic Endoscopic Mucosal Remission (HEMR): Endoscopy Subscore of 0 and Geboes Score < 2.0) at Week 12 Week 12 Mucosal healing defined as endoscopic and histologic remission.
Sub-Study 1: Percentage of Participants Achieving Endoscopic Remission Week 12 Endoscopic remission per endoscopy subscore.
Sub-Study 1: Change in Ulcerative Colitis Symptom Questionnaire (UC-SQ) Baseline Through Week 12 The US-SQ is a patient questionnaire to assess severity of Crohn's symptoms.
Sub-Study 1: Change in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Baseline Through Week 12 The FACIT-Fatigue is a validated tool that measures an individual's level of fatigue during their usual daily activities over the past week.
Sub-Study 2: Occurrence of UC-related Hospitalizations Baseline Through Week 12 Participants with an UC-related event that results in admission to the hospital.
Sub-Study 2: Percentage of Participants Achieving No Tenesmus Week 12 Percentage of participants who reported no tenesmus.
Sub-Study 2: Change in Number of Days per Week with Sleep Interrupted due to UC Symptoms Baseline to Week 12 Change in number of days per week with sleep interrupted due to UC symptoms.
Sub-Study 1: Percentage of Participants Achieving Clinical Response per Adapted Mayo Score Week 12 Clinical response per adapted Mayo Score.
Sub-Study 1: Change in Inflammatory Bowel Disease Questionnaire (IBDQ) Baseline Through Week 12 The IBDQ is used to assess the quality of life of patients with inflammatory bowel disease.
Sub-Study 1: Change in Short Form-36 (SF-36) Baseline Through Week 12 The SF-36 is an indicator of overall health status.
Sub-Study 1: Percentage of Participants Undergoing Ulcerative Colitis (UC)-related Surgeries Through Week 12 Participants who underwent surgery related to UC.
Sub-Study 2: Percentage of Participants Achieving Clinical Response per Adapted Mayo Score Week 12 Clinical response per adapted Mayo Score.
Sub-Study 2: Percentage of Participants Achieving Endoscopic Improvement Week 12 Endoscopic improvement per endoscopy subscore.
Sub-Study 2: Percentage of Participants Achieving Histologic Endoscopic Mucosal Improvement (HEMI) Week 12 Endoscopic subscore of 0 or 1 without evidence of friability and Geboes score ≤ 3.1) at Week 12
Sub-Study 2: Percentage of Participants Achieving No Abdominal Pain Week 12 Percentage of participants who reported no abdominal pain.
Sub-Study 2: Change in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Baseline to Week 12 The FACIT-Fatigue is a validated tool that measures an individual's level of fatigue during their usual daily activities over the past week.
Sub-Study 2: Percentage of Participants Achieving No Nocturnal Bowel Movements Week 12 Percentage of participants who reported no nocturnal bowel movements.
Trial Locations
- Locations (430)
Private Practice Dr MN Rajabally /ID# 171137
🇿🇦Cape Town, Western Cape, South Africa
Massachusetts General Hospital - Crohn's and Colitis Center /ID# 164255
🇺🇸Boston, Massachusetts, United States
Cedars-Sinai Medical Center-West Hollywood /ID# 163851
🇺🇸West Hollywood, California, United States
Atlanta Gastroenterology Spec /ID# 161372
🇺🇸Suwanee, Georgia, United States
The University of Chicago Medical Center /ID# 160521
🇺🇸Chicago, Illinois, United States
Ctr for Advanced Gastroenterol /ID# 202811
🇺🇸Maitland, Florida, United States
Carolina Research /ID# 201090
🇺🇸Greenville, North Carolina, United States
Medical Research Center of CT /ID# 160311
🇺🇸Hamden, Connecticut, United States
United Medical Doctors /ID# 158528
🇺🇸Los Alamitos, California, United States
Univ Kansas Med Ctr /ID# 226602
🇺🇸Kansas City, Kansas, United States
University of Rochester Medical Center /ID# 161664
🇺🇸Rochester, New York, United States
Plains Clinical Research Center, LLC /ID# 169732
🇺🇸Fargo, North Dakota, United States
Louisana Research Center, LLC /ID# 201204
🇺🇸Shreveport, Louisiana, United States
Atrium Health Carolinas Medical Center /ID# 158512
🇺🇸Charlotte, North Carolina, United States
DiGiovanna Institute for Medical Education & Research /ID# 171129
🇺🇸North Massapequa, New York, United States
Advanced Research Institute, Inc /ID# 161938
🇺🇸New Port Richey, Florida, United States
Weill Cornell Medicine /ID# 165887
🇺🇸New York, New York, United States
Columbia Univ Medical Center /ID# 161934
🇺🇸New York, New York, United States
Lenox Hill Hospital /ID# 168470
🇺🇸New York, New York, United States
Gastro One /ID# 160418
🇺🇸Cordova, Tennessee, United States
Texas Digestive Disease Consultants /ID# 209950
🇺🇸Cedar Park, Texas, United States
DHAT Research Institute /ID# 158226
🇺🇸Garland, Texas, United States
Gastro Health & Nutrition - Victoria /ID# 164321
🇺🇸Victoria, Texas, United States
Hospital Nossa Senhora das Graças /ID# 157671
🇧🇷Curitiba, Parana, Brazil
Tyler Research Institute, LLC /ID# 166800
🇺🇸Tyler, Texas, United States
Universitair Ziekenhuis Leuven /ID# 170812
🇧🇪Leuven, Vlaams-Brabant, Belgium
APHM - Hopital Nord /ID# 225825
🇫🇷Marseille, Bouches-du-Rhone, France
Praxiszentrum fuer Gastroenterologie /ID# 219069
🇩🇪Grevenbroich, Nordrhein-Westfalen, Germany
Second Multiprofile Hospital f /ID# 200799
🇧🇬Sofia, Bulgaria
Baylor Scott & White Center for Diagnostic Medicine /ID# 204130
🇺🇸Temple, Texas, United States
UMHAT Kaspela EOOD /ID# 200797
🇧🇬Plovdiv, Bulgaria
Hopital Beaujon /ID# 200092
🇫🇷Clichy, Ile-de-France, France
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 157660
🇧🇷Ribeirão Preto, Sao Paulo, Brazil
Hotel Dieu de Levis /ID# 214378
🇨🇦Lévis, Quebec, Canada
UMHAT Tsaritsa Joanna - ISUL /ID# 209977
🇧🇬Sofia, Bulgaria
Hospital Las Higueras /ID# 167093
🇨🇱Talcahuano, Chile
Scott Shulman Medicine Professional Corporation /ID# 169113
🇨🇦North Bay, Ontario, Canada
The Sixth Affiliated Hosp Sun /ID# 211231
🇨🇳Guangzhou, Guangdong, China
CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 169108
🇨🇦Montreal, Quebec, Canada
Hospital Guillermo Grant Benavente de Concepción /ID# 210761
🇨🇱Concepción, Chile
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159361
🇩🇪Berlin, Germany
CHU Amiens-Picardie Site Sud /ID# 171576
🇫🇷Amiens CEDEX 1, Somme, France
Centre Médico Chirurgical Ambroise Paré Hartmann /ID# 249860
🇫🇷Neuilly Sur Seine, Ile-de-France, France
Praxis fuer Gastroenterologie /ID# 166152
🇩🇪Heidelberg, Baden-Wuerttemberg, Germany
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 170915
🇬🇷Athens, Attiki, Greece
Stadtisches Klinikum Braunschweig /ID# 163687
🇩🇪Braunschweig, Germany
General Hospital of Athens Ippokratio /ID# 229189
🇬🇷Athens, Attiki, Greece
Klinikum Lueneburg /ID# 163685
🇩🇪Lueneburg, Germany
EUGASTRO GmbH /ID# 219070
🇩🇪Leipzig, Germany
Fukuoka University Chikushi Hospital /ID# 209055
🇯🇵Chikushino-shi, Fukuoka, Japan
NHO Shizuoka Medical Center /ID# 164435
🇯🇵Sunto-gun, Shizuoka, Japan
Yonsei University Health System Severance Hospital /ID# 158701
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Dong-A University Hospital /ID# 158705
🇰🇷Busan, Korea, Republic of
Pusan National University Hospital /ID# 158711
🇰🇷Busan, Korea, Republic of
Kangbuk Samsung Hospital /ID# 158707
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Gokeikai Ofuna Chuo Hospital /ID# 169300
🇯🇵Kamakura-shi, Kanagawa, Japan
Mie University Hospital /ID# 203633
🇯🇵Tsu-shi, Mie, Japan
Matsuda Hospital /ID# 226616
🇯🇵Hamamatsu-shi, Shizuoka, Japan
The Catholic University of Korea, ST. Vincent's Hospital /ID# 158706
🇰🇷Suwon, Gyeonggido, Korea, Republic of
Yeungnam University Medical Center /ID# 158703
🇰🇷Daegu, Korea, Republic of
Yokkaichi Hazu Medical Center /ID# 164441
🇯🇵Yokkaichi-shi, Mie, Japan
Nara Medical University Hospital /ID# 169225
🇯🇵Kashihara-shi, Nara, Japan
Tokuyama Central Hospital /ID# 226011
🇯🇵Shunan-shi, Yamaguchi, Japan
Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 165582
🇵🇹Lisboa, Portugal
Cabinet Particular Policlinic Algomed /ID# 171266
🇷🇴Timișoara, Romania
NTT Medical Center Tokyo /ID# 225587
🇯🇵Shinagawa-ku, Tokyo, Japan
Pauls Stradins Clinical University Hospital /ID# 163803
🇱🇻Riga, Latvia
CHA University Bundang Medical Center /ID# 158710
🇰🇷Seongnam si, Gyeonggido, Korea, Republic of
The Jikei University Hospital /ID# 164434
🇯🇵Minato-ku, Tokyo, Japan
Inje University Haeundae Hospital /ID# 203028
🇰🇷Busan, Korea, Republic of
The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 242378
🇰🇷Daejeon, Korea, Republic of
Waikato Hospital /ID# 212789
🇳🇿Hamilton, Waikato, New Zealand
Universiti Sains Malaysia /ID# 221971
🇲🇾Kelantan, Malaysia
Academisch Medisch Centrum /ID# 157959
🇳🇱Amsterdam, Netherlands
Elisabeth Tweesteden Ziekenhuis /ID# 163767
🇳🇱Tilburg, Netherlands
Christchurch Hospital /ID# 205342
🇳🇿Christchurch, Canterbury, New Zealand
Vitamed Gałaj i Cichomski Sp.j. /ID# 213283
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
WIP Warsaw IBD Point Profesor Kierkus /ID# 216102
🇵🇱Warsaw, Mazowieckie, Poland
Centro Hospitalar de Entre Douro e Vouga /ID# 166052
🇵🇹Santa Maria Da Feira, Porto, Portugal
Centro Hospitalar e Universitario de Coimbra, EPE /ID# 166054
🇵🇹Coimbra, Portugal
Centrum Zdrowia MDM /ID# 170597
🇵🇱Warszawa, Mazowieckie, Poland
NZOZ All-Medicus /ID# 170596
🇵🇱Katowice, Slaskie, Poland
H-T. Centrum Medyczne - Endoterapia /ID# 230979
🇵🇱Tychy, Slaskie, Poland
Danderyds sjukhus AB /ID# 202035
🇸🇪Stockholm, Sweden
Spoke Research Inc /ID# 229905
🇿🇦CAPE TOWN Milnerton, Western Cape, South Africa
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 158041
🇬🇧Newcastle upon Tyne, United Kingdom
King's College Hospital NHS Foundation Trust /ID# 158766
🇬🇧London, United Kingdom
Complejo Hospitalario Universitario de Pontevedra /ID# 216182
🇪🇸Pontevedra, Spain
Erciyes University Medical Fac /ID# 171291
🇹🇷Melikgazi, Kayseri, Turkey
Hospital de Cabuenes /ID# 170748
🇪🇸Gijon, Asturias, Spain
Chung Shan Medical University Hospital /ID# 163651
🇨🇳Taichung, Taiwan
Inonu Universitesi Turgut Ozal /ID# 203981
🇹🇷Battalgazi/malatya, Turkey
Hospital Universitario Miguel Servet /ID# 159445
🇪🇸Zaragoza, Spain
Hospital Clinic de Barcelona /ID# 159439
🇪🇸Barcelona, Spain
Dr JP Wright /ID# 171138
🇿🇦Cape Town, Western Cape, South Africa
Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159461
🇪🇸Sabadell, Barcelona, Spain
Universitatsspital Zurich /ID# 202910
🇨🇭Zurich, Zuerich, Switzerland
Taichung Veterans General Hospital /ID# 163649
🇨🇳Taichung, Taiwan
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 167207
🇹🇷Istanbul, Turkey
Alingsas lasarett /ID# 202074
🇸🇪Alingsas, Vastra Gotalands Lan, Sweden
Cambridge University Hospitals NHS Foundation Trust /ID# 158040
🇬🇧Cambridge, United Kingdom
Liverpool University Hospitals NHS Foundation Trust /ID# 203858
🇬🇧Liverpool, United Kingdom
Hospital Universitario Reina Sofia /ID# 167058
🇪🇸Cordoba, Spain
Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 159440
🇪🇸Ferrol, A Coruna, Spain
Hospital Universitario La Paz /ID# 159459
🇪🇸Madrid, Spain
Sahlgrenska University Hospital Molndal /ID# 202843
🇸🇪Molndal, Vastra Gotalands Lan, Sweden
Barts Health NHS Trust /ID# 157590
🇬🇧London, London, City Of, United Kingdom
Barnsley Hospital NHS Foundation Trust /ID# 202770
🇬🇧Barnsley, United Kingdom
Hospital Universitario Puerta de Hierro, Majadahonda /ID# 159443
🇪🇸Majadahonda, Madrid, Spain
Hospital Universitario Virgen Macarena /ID# 159968
🇪🇸Sevilla, Spain
Vilo Research Group Inc /ID# 207656
🇺🇸Houston, Texas, United States
CliniCore International, LLC /ID# 158218
🇺🇸Houston, Texas, United States
Centex Studies, Inc. - Houston /ID# 201222
🇺🇸Houston, Texas, United States
University of Miami /ID# 160471
🇺🇸Miami, Florida, United States
South Florida Research Ph I-IV, Inc. /ID# 161848
🇺🇸Miami, Florida, United States
Coral Research Clinic /ID# 158584
🇺🇸Miami, Florida, United States
Indiana University /ID# 167252
🇺🇸Indianapolis, Indiana, United States
Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 211064
🇨🇳Hangzhou, Zhejiang, China
Hospital Provincial del Centenario /ID# 170898
🇦🇷Rosario, Santa Fe, Argentina
Medizinische Universitaet Graz /ID# 169053
🇦🇹Graz, Steiermark, Austria
CHU Bordeaux - Hopital Haut Leveque /ID# 171579
🇫🇷Pessac, Gironde, France
Covenant Health /ID# 169114
🇨🇦Edmonton, Alberta, Canada
The Chaim Sheba Medical Center /ID# 211278
🇮🇱Ramat Gan, Tel-Aviv, Israel
Tokatsu Tsujinaka Hospital /ID# 164438
🇯🇵Abiko-shi, Chiba, Japan
Chiba University Hospital /ID# 209632
🇯🇵Chiba-shi, Chiba, Japan
Soroka University Medical Center /ID# 171100
🇮🇱Be'er Sheva, HaDarom, Israel
Rabin Medical Center /ID# 167403
🇮🇱Petakh Tikva, Israel
University of Catanzaro /ID# 200125
🇮🇹Catanzaro, Calabria, Italy
National Hospital Organization Hirosaki General Medical Center /ID# 164252
🇯🇵Hirosaki-shi, Aomori, Japan
Saiseikai Fukuoka Genaral Hospital /ID# 225639
🇯🇵Fukuoka-shi, Fukuoka, Japan
Kanazawa University Hospital /ID# 169224
🇯🇵Kanazawa-shi, Ishikawa, Japan
St.Luke's International Hospital /ID# 225822
🇯🇵Chuo-ku, Tokyo, Japan
Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 163992
🇮🇹Rome, Lazio, Italy
Allergy & Immunology (AIU) /ID# 171441
🇿🇦Cape Town, Western Cape, South Africa
Teikyo University Hospital /ID# 225588
🇯🇵Itabashi-ku, Tokyo, Japan
Kyorin University Hospital /ID# 164259
🇯🇵Mitaka-shi, Tokyo, Japan
Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 166551
🇵🇹Portimão, Faro, Portugal
National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 203512
🇷🇺Moscow, Russian Federation
Toho University Sakura Medical Center /ID# 164254
🇯🇵Sakura-shi, Chiba, Japan
Sapporo IBD Clinic /ID# 225923
🇯🇵Sapporo-shi, Hokkaido, Japan
Tokitokai Tokito clinic /ID# 164253
🇯🇵Saitama-shi, Saitama, Japan
Tokyo Medical And Dental University Hospital /ID# 164258
🇯🇵Bunkyo-ku, Tokyo, Japan
Tokai University Hachioji Hospital /ID# 226899
🇯🇵Hachioji-shi, Tokyo, Japan
Arsvita Clinic /ID# 208946
🇷🇺Korolev, Moskovskaya Oblast, Russian Federation
Hiroshima University Hospital /ID# 164426
🇯🇵Hiroshima-shi, Hiroshima, Japan
Asahikawa Medical University Hospital /ID# 164433
🇯🇵Asahikawa-shi, Hokkaido, Japan
Sapporo Medical University Hospital /ID# 164432
🇯🇵Sapporo-shi, Hokkaido, Japan
Sapporo Higashi Tokushukai Hospital /ID# 208488
🇯🇵Sapporo-shi, Hokkaido, Japan
Keio University Hospital /ID# 203629
🇯🇵Shinjuku-ku, Tokyo, Japan
Vilnius University Hospital Santaros Klinikos /ID# 170614
🇱🇹Vilnius, Lithuania
Fundeni Clinical Institute /ID# 171264
🇷🇴Bucharest, Romania
Immanuel Kant Baltic Federal University /ID# 204888
🇷🇺Kaliningrad, Kaliningradskaya Oblast, Russian Federation
Inselspital, Universitätsspital Bern /ID# 202911
🇨🇭Bern, Switzerland
National Taiwan University Hospital /ID# 162187
🇨🇳Taipei City, Taiwan
Hospital Alvaro Cunqueiro CHUVI /ID# 167360
🇪🇸Vigo, Pontevedra, Spain
Linkou Chang Gung Memorial Hospital /ID# 222877
🇨🇳Taoyuan City, Taiwan
Acibadem Kozyatagi Hospital /ID# 213276
🇹🇷Kadikoy, Istanbul, Turkey
Ankara Univ Medical Faculty /ID# 167210
🇹🇷Ankara, Turkey
Fırat University Medical Facul /ID# 171292
🇹🇷Elazig, Turkey
Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 224350
🇺🇦Kherson, Ukraine
Taipei Veterans General Hosp /ID# 163650
🇨🇳Taipei, Taiwan
China Medical University Hospital /ID# 160189
🇨🇳Taichung, Taiwan
Sisli Etfal Train & Res Hosp /ID# 171409
🇹🇷Sisli, Turkey
Uludag University Medical Faculty /ID# 204182
🇹🇷Bursa, Turkey
CNE Regional Clinical Hospital of Ivano-Frankivsk RC /ID# 203367
🇺🇦Ivano-frankivsk, Ukraine
Kyiv Municipal Clinical Hospital #18 /ID# 224348
🇺🇦Kyiv, Ukraine
Medical Center "OK!Clinic+" /ID# 205482
🇺🇦Kyiv, Ukraine
CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 224343
🇺🇦Kyiv, Ukraine
Manhattan Clinical Research, LLC /ID# 211805
🇺🇸New York, New York, United States
Cotton-O'Neil Clinical Res Ctr /ID# 160412
🇺🇸Topeka, Kansas, United States
Rocky Mountain Pediatric Gastroenterology /ID# 207174
🇺🇸Lone Tree, Colorado, United States
Peak Gastroenterology Associates, PC /ID# 165841
🇺🇸Colorado Springs, Colorado, United States
CHU UCL Namur - site Godinne /ID# 200254
🇧🇪Godinne, Namur, Belgium
The Ohio State University /ID# 164714
🇺🇸Columbus, Ohio, United States
Hoag Memorial Hosp Presbyterian /ID# 218348
🇺🇸Irvine, California, United States
UC San Diego Health System /ID# 160452
🇺🇸La Jolla, California, United States
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 200931
🇺🇸Los Angeles, California, United States
South Lake Pain Institute, Inc /ID# 162878
🇺🇸Clermont, Florida, United States
Gastroenterology Group Naples /ID# 165212
🇺🇸Naples, Florida, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 160523
🇺🇸Macon, Georgia, United States
Optimed Research, Ltd. /ID# 167113
🇺🇸Columbus, Ohio, United States
ProMedica Physicians Digestive Healthcare /ID# 215623
🇺🇸Sylvania, Ohio, United States
Digestive Disease Associates, LTD /ID# 232407
🇺🇸Wyomissing, Pennsylvania, United States
Penn State Milton S. Hershey Medical Center /ID# 223563
🇺🇸Hershey, Pennsylvania, United States
Adult Gastroenterology Associates - Gen 1 Research /ID# 208867
🇺🇸Tulsa, Oklahoma, United States
University of Pennsylvania /ID# 166266
🇺🇸Philadelphia, Pennsylvania, United States
East Tennessee Research Institute /ID# 168747
🇺🇸Johnson City, Tennessee, United States
Gastroenterology Associates, P.A. of Greenville /ID# 160472
🇺🇸Greenville, South Carolina, United States
Inquest Clinical Research /ID# 165685
🇺🇸Baytown, Texas, United States
Baylor College of Medicine - Baylor Medical Center /ID# 158221
🇺🇸Houston, Texas, United States
Texas Digestive Disease Consultants /ID# 209798
🇺🇸Cedar Park, Texas, United States
Precision Research Institute, LLC /ID# 201351
🇺🇸Houston, Texas, United States
Caprock Gastro Research, LLC /ID# 215432
🇺🇸Lubbock, Texas, United States
Advanced Research Institute /ID# 160480
🇺🇸Ogden, Utah, United States
Gastroenterology Consultants of Southwest Virginia /ID# 218143
🇺🇸Roanoke, Virginia, United States
Virginia Mason Medical Center /ID# 160466
🇺🇸Seattle, Washington, United States
Gedyt /ID# 243423
🇦🇷Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
Hospital Privado Univesitario /ID# 167779
🇦🇷Cordoba, Argentina
Sanatorio 9 de Julio /ID# 167780
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Duplicate_Universitaetsklinikum St.Poelten /ID# 169048
🇦🇹St. Poelten, Niederoesterreich, Austria
Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 215320
🇦🇹Linz, Oberoesterreich, Austria
Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 200685
🇦🇹Salzburg, Austria
Medizinische Universitaet Wien /ID# 169050
🇦🇹Vienna, Wien, Austria
Cliniques Universitaires de Bruxelles Hopital Erasme /ID# 200252
🇧🇪Brussels, Bruxelles-Capitale, Belgium
UCL Saint-Luc /ID# 200039
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
AZ-Delta /ID# 200040
🇧🇪Roeselare, West-Vlaanderen, Belgium
Imelda Ziekenhuis /ID# 211100
🇧🇪Bonheiden, Belgium
CHU de Liege /ID# 200253
🇧🇪Liege, Belgium
Groupe Sante CHC - Clinique du MontLegia /ID# 200250
🇧🇪Liege, Belgium
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 157679
🇧🇷Goiânia, Goias, Brazil
Upeclin Fmb - Unesp /Id# 157690
🇧🇷Botucatu, Sao Paulo, Brazil
Kaiser Clinica e Hospital Dia /ID# 157680
🇧🇷Sao Jose Do Rio Preto, Sao Paulo, Brazil
Hospital de Clinicas de Porto Alegre /ID# 157662
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Faculdade de Medicina do ABC /ID# 163995
🇧🇷Santo André, Sao Paulo, Brazil
MHAT Hadzhi Dimitar /ID# 207945
🇧🇬Sliven, Bulgaria
UMHAT Sveti Ivan Rilski /ID# 210797
🇧🇬Sofia, Bulgaria
Fraser Clinical Trials Inc /ID# 169102
🇨🇦New Westminster, British Columbia, Canada
Allen Whey Khye Lim Professional Corporation /ID# 169767
🇨🇦Edmonton, Alberta, Canada
Percuro Clinical Research, Ltd /ID# 169109
🇨🇦Victoria, British Columbia, Canada
Toronto Digestive Disease Asso /ID# 169106
🇨🇦Vaughan, Ontario, Canada
London Health Sciences Center /ID# 169103
🇨🇦London, Ontario, Canada
Royal Victoria Hospital / McGill University Health Centre /ID# 169104
🇨🇦Montreal, Quebec, Canada
Servicio de Salud Araucanía Norte Hospital Victoria /ID# 213151
🇨🇱Victoria, Araucania, Chile
Complejo Asistencial Dr. Sotero del Rio /ID# 169385
🇨🇱Santiago, Region Metropolitana Santiago, Chile
Servicio de Salud Occidente Hospital San Juan de Dios /ID# 171125
🇨🇱Santiago, Region Metropolitana Santiago, Chile
The First Affiliated Hospital of Anhui Medical University /ID# 211228
🇨🇳Hefei, Anhui, China
Beijing Friendship Hospital /ID# 211066
🇨🇳Beijing, Beijing, China
Tongji Hospital Tongji Medical College of HUST /ID# 211072
🇨🇳Wuhan, Hubei, China
The Second Hospital of Hebei Medical University /ID# 213018
🇨🇳Shijiazhuang, Hebei, China
Renmin Hospital of Wuhan University /ID# 212868
🇨🇳Wuhan, Hubei, China
Huai'an First People's Hospital /ID# 239196
🇨🇳Huaian, Jiangsu, China
Nanjing Drum Tower Hospital /ID# 227439
🇨🇳Nanjing, Jiangsu, China
Jiangsu Province Hospital /ID# 211232
🇨🇳Nanjing, Jiangsu, China
The First Affiliated Hospital of Nanchang University /ID# 212183
🇨🇳Nanchang, Jiangxi, China
The First Hospital of Jilin University /ID# 212278
🇨🇳Changchun, Jilin, China
Shanghai East Hospital /ID# 218791
🇨🇳Pudong New District, Shanghai, China
Wuxi People's Hospital /ID# 218798
🇨🇳Wuxi, Jiangsu, China
General Hospital of Ningxia Medical University /ID# 213911
🇨🇳Yinchuan City, Ningxia, China
Xijing Hospital /ID# 211639
🇨🇳Xi'an, Shaanxi, China
Tangdu Hospital of The Fourth Military Medical University, PLA /ID# 215504
🇨🇳Xi'an, Shaanxi, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210962
🇨🇳Shanghai, Shanghai, China
Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 211233
🇨🇳Shanghai, Shanghai, China
Shanghai General Hospital /ID# 226190
🇨🇳Shanghai, Shanghai, China
West China Hospital, Sichuan University /ID# 211276
🇨🇳Chengdu, Sichuan, China
The second Affiliated hospital of Zhejiang University school of Medicine /ID# 211025
🇨🇳Hangzhou, Zhejiang, China
The Second Xiangya Hospital of Central South University /ID# 211198
🇨🇳Changsha, China
Shengjing Hospital of China Medical University /ID# 211646
🇨🇳Shenyang, China
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 211071
🇨🇳Wuhan, China
Oncomédica SAS /ID# 206937
🇨🇴Monteria, Cordoba, Colombia
Hospital Universitario San Vic /ID# 171490
🇨🇴Medellin, Colombia
Clinical Hospital Dubrava /ID# 157475
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Osijek /ID# 157472
🇭🇷Osijek, Osjecko-baranjska Zupanija, Croatia
Klinicki bolnicki centar Zagreb /ID# 157471
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Zagreb /ID# 201917
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Split /ID# 157473
🇭🇷Split, Splitsko-dalmatinska Zupanija, Croatia
Fakultni nemocnice u sv. Anny v Brne /ID# 239157
🇨🇿Brno, Czechia
Nemocnice Ceske Budejovice a.s. /ID# 225226
🇨🇿Ceske Budejovice, Czechia
Hepato-Gastroenterologie HK, s.r.o. /ID# 163395
🇨🇿Hradec Kralove, Czechia
Fakultni nemocnice Ostrava /ID# 225567
🇨🇿Ostrava, Czechia
Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 202266
🇩🇰Hvidovre, Hovedstaden, Denmark
Odense University Hospital /ID# 205602
🇩🇰Odense C, Syddanmark, Denmark
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 200848
🇪🇬Alexandria, Egypt
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 226793
🇪🇬Alexandria, Egypt
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 226794
🇪🇬Alexandria, Egypt
Air Force Specialized Hospital /ID# 170986
🇪🇬Cairo, Egypt
National Liver Institute /ID# 171040
🇪🇬Menoufiya, Egypt
Chu de Nice-Hopital L'Archet Ii /Id# 171577
🇫🇷Nice, Alpes-Maritimes, France
CHRU Nancy - Hopitaux de Brabois /ID# 200095
🇫🇷Vandoeuvre-les-Nancy, Meurthe-et-Moselle, France
CHU de SAINT ETIENNE - Hopital Nord /ID# 171580
🇫🇷St. Priest En Jarez, Loire, France
Clinique Jules Verne /ID# 240976
🇫🇷Nantes, France
Universitatsklinikum Mannheim /ID# 162035
🇩🇪Mannheim, Baden-Wuerttemberg, Germany
Universitaetsklinikum Erlangen /ID# 159354
🇩🇪Erlangen, Bayern, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159360
🇩🇪Kiel, Schleswig-Holstein, Germany
Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 219145
🇩🇪Berlin, Germany
Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 210510
🇩🇪Berlin, Germany
DRK Kliniken Berlin Westend /ID# 166153
🇩🇪Berlin, Germany
Agaplesion Markus Krankenhaus /ID# 159356
🇩🇪Frankfurt am Main, Germany
Gastroenterologie Opernstrasse /ID# 163683
🇩🇪Kassel, Germany
Gastroenterologische Gemeinschaftspraxis Minden /ID# 162033
🇩🇪Minden, Germany
Universitaetsklinikum Regensburg /ID# 163686
🇩🇪Regensburg, Germany
LMU Klinikum Campus Grosshadern /ID# 210481
🇩🇪München, Germany
General Hospital of Athens Laiko /ID# 206440
🇬🇷Athens, Attiki, Greece
Tzaneio general hospital of Piraeus /ID# 206439
🇬🇷Piraeus, Attiki, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 217480
🇬🇷Athens, Greece
General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 165218
🇬🇷Pireaus, Greece
Theageneio Anticancer Hospital /ID# 165217
🇬🇷Thessaloniki, Greece
Hadassah Medical Center-Hebrew University /ID# 171099
🇮🇱Jerusalem, Yerushalayim, Israel
Rambam Health Care Campus /ID# 171103
🇮🇱Haifa, Israel
Shaare Zedek Medical Center /ID# 163544
🇮🇱Jerusalem, Israel
Azienda Ospedaliera San Camillo Forlanini /ID# 155612
🇮🇹Rome, Lazio, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 171226
🇮🇹Rome, Lazio, Italy
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 164041
🇮🇹Negrar, Verona, Italy
Aichi Medical University Hospital /ID# 164332
🇯🇵Nagakute-shi, Aichi, Japan
Nagoya City University Hospital /ID# 164331
🇯🇵Nagoya shi, Aichi, Japan
Daido Clinic /ID# 211479
🇯🇵Nagoya-shi, Aichi, Japan
Nagoya University Hospital /ID# 164271
🇯🇵Nagoya-shi, Aichi, Japan
Fujita Health University Hospital /ID# 164261
🇯🇵Toyoake-shi, Aichi, Japan
Tsujinaka Hospital Kashiwanoha /ID# 208964
🇯🇵Kashiwa-shi, Chiba, Japan
Fukuoka University Hospital /ID# 226189
🇯🇵Fukuoka-shi, Fukuoka, Japan
Kurume University Hospital /ID# 164427
🇯🇵Kurume-shi, Fukuoka, Japan
Gifu University Hospital /ID# 208081
🇯🇵Gifu-shi, Gifu, Japan
NHO Fukuyama Medical Center /ID# 164439
🇯🇵Fukuyama-shi, Hiroshima, Japan
Ogaki Municipal Hospital /ID# 226010
🇯🇵Ogaki-shi, Gifu, Japan
National Hospital Organization Takasaki General Medical Center /ID# 164437
🇯🇵Takasaki-shi, Gunma, Japan
Aoyama Clinic /ID# 164425
🇯🇵Kobe-shi, Hyogo, Japan
Hyogo Medical University Hospital /ID# 164424
🇯🇵Nishinomiya-shi, Hyogo, Japan
Sameshima Hospital /ID# 211181
🇯🇵Kagoshima-shi, Kagoshima, Japan
Tokai University Hospital /ID# 209204
🇯🇵Isehara-shi, Kanagawa, Japan
Kitasato University Hospital /ID# 169226
🇯🇵Sagamihara-shi, Kanagawa, Japan
Colo-proctology Center Matsushima Clinic /ID# 225914
🇯🇵Yokohama-shi, Kanagawa, Japan
Nagasaki University Hospital /ID# 202674
🇯🇵Nagasaki-shi, Nagasaki, Japan
Tohoku University Hospital /ID# 164430
🇯🇵Sendai-shi, Miyagi, Japan
Kinshukai Infusion Clinic /ID# 226747
🇯🇵Osaka-shi, Osaka, Japan
Saga University Hospital /ID# 209396
🇯🇵Saga-shi, Saga, Japan
Osaka Medical and Pharmaceutical University Hospital /ID# 226035
🇯🇵Takatsuki-shi, Osaka, Japan
Shiga University of Medical Science Hospital /ID# 164440
🇯🇵Otsu-shi, Shiga, Japan
Hamamatsu University Hospital /ID# 226727
🇯🇵Hamamatsu-shi, Shizuoka, Japan
Hanyang University Gurihospital /ID# 158702
🇰🇷Guri, Gyeonggido, Korea, Republic of
Samsung Medical Center /ID# 158704
🇰🇷Seoul, Korea, Republic of
VCA Polyclinic Aura /ID# 163802
🇱🇻Riga, Latvia
JM Research SC /ID# 203593
🇲🇽Cuernavaca, Morelos, Mexico
Unidad de Atencion Medica e Investigacion en Salud /ID# 203595
🇲🇽Merida, Yucatan, Mexico
Health Pharma Professional Research S.A de C.V /ID# 203597
🇲🇽Del. Benito Juárez, Mexico
Tauranga Hospital /ID# 212792
🇳🇿Tauranga South, Bay Of Plenty, New Zealand
Wellington Regional Hospital /ID# 205343
🇳🇿Newtown, Wellington, New Zealand
Vistamed /ID# 210105
🇵🇱Wroclaw, Dolnoslaskie, Poland
Hutt Hospital /ID# 212786
🇳🇿Lower Hutt, New Zealand
Dunedin Hospital /ID# 212790
🇳🇿Otago, New Zealand
Gastromed Sp. z o.o /ID# 230978
🇵🇱Torun, Kujawsko-pomorskie, Poland
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie Panstwowy Instytut Bada /ID# 170600
🇵🇱Warszawa, Mazowieckie, Poland
Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 170601
🇵🇱Warszawa, Mazowieckie, Poland
Endoskopia Sp. z o.o. /ID# 170598
🇵🇱Sopot, Pomorskie, Poland
Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 165580
🇵🇹Guimaraes, Braga, Portugal
Hospital Garcia de Orta, EPE /ID# 165583
🇵🇹Almada, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 165581
🇵🇹Porto, Portugal
Sana Monitoring /Id# 224166
🇷🇴Bucharest, Romania
San Jorge Children Hospital /ID# 166954
🇵🇷San Juan, Puerto Rico
Clinica GASTRO MED SRL /ID# 224169
🇷🇴Cluj-Napoca, Cluj, Romania
Fundeni Clinical Institute /ID# 224168
🇷🇴Bucharest, Romania
VA Caribbean Healthcare System /ID# 221245
🇵🇷San Juan, Puerto Rico
Duplicate_Centrul Medical Tuculanu SRL /ID# 171268
🇷🇴Timisoara, Romania
GBUZ Allergology and Immunology Center of Ministry of Health of Kabardino-Bal /ID# 233973
🇷🇺Nalchik, Kabardino-Balkarskaya Respublika, Russian Federation
Kuzbass Regional Clinical Hospital /ID# 165750
🇷🇺Kemerovo, Kemerovskaya Oblast, Russian Federation
Clinic of New Technologies of Medicine /ID# 203369
🇷🇺Dzerzhinskiy, Russian Federation
Uninova Medical Center /ID# 229216
🇷🇺Saint Petersburg, Leningradskaya Oblast, Russian Federation
Perm Clinical Center of the Federal Medical and Biological Agency /ID# 227457
🇷🇺Perm, Permskiy Kray, Russian Federation
First Moscow State Medical University n.a I.M. Sechenov /ID# 204978
🇷🇺Moscow, Russian Federation
Regional Clinical Hospital #1 /ID# 165754
🇷🇺Tyumen, Tyumenskaya Oblast, Russian Federation
City Clinical Hospital #40 /ID# 203370
🇷🇺Sestroretsk, Sankt-Peterburg, Russian Federation
Central Clinical Hospital RZHD Medicine /ID# 204917
🇷🇺Moscow, Russian Federation
Novosibirski Gastrocenter /ID# 229855
🇷🇺Novosibirsk, Russian Federation
Euromedservice /ID# 204892
🇷🇺Pushkin, Russian Federation
Ulyanovsk Regional Clinical Hospital /ID# 203368
🇷🇺Ulyanovsk, Russian Federation
Clinical Hosp Center Zvezdara /ID# 200151
🇷🇸Belgrade, Beograd, Serbia
International Medical Center SOGAZ /ID# 206727
🇷🇺St. Petersburg, Russian Federation
University Clinical Center Serbia /ID# 200152
🇷🇸Belgrade, Beograd, Serbia
Clin Hosp Ctr Bezanijska Kosa /ID# 202059
🇷🇸Belgrade, Beograd, Serbia
Clinical Center Vojvodina /ID# 156910
🇷🇸Novi Sad, Vojvodina, Serbia
Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 224926
🇷🇸Belgrade, Serbia
General Hospital Leskovac /ID# 207226
🇷🇸Leskovac, Serbia
KL Ling Gastroenterology and Liver Clinic /ID# 205738
🇸🇬Singapore, Singapore
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 164347
🇸🇰Banska Bystrica, Slovakia
KM Management, spol. s.r.o. /ID# 206602
🇸🇰Nitra, Slovakia
Fakultna nemocnica s poliklinikou Nove Zamky /ID# 224099
🇸🇰Nove Zamky, Slovakia
GASTRO I., s.r.o. /ID# 164346
🇸🇰Presov, Slovakia
Univ Medical Ctr Ljubljana /ID# 210627
🇸🇮Ljubljana, Slovenia
Farmovs (Pty) Ltd /Id# 207537
🇿🇦Bloemfontein, Free State, South Africa
Clinresco Centers /ID# 239824
🇿🇦Johannesburg, Gauteng, South Africa
NHS Lothian /ID# 208802
🇬🇧Edinburgh, United Kingdom
St George's University Hospitals NHS Foundation Trust /ID# 208378
🇬🇧Tooting, United Kingdom
Bispebjerg and Frederiksberg Hospital /ID# 208945
🇩🇰Copenhagen NV, Hovedstaden, Denmark
Sjællands Universitetshospital /ID# 200033
🇩🇰Roskilde, Sjælland, Denmark
Ospedale Policlinico San Martino /ID# 164031
🇮🇹Genoa, Genova, Italy
Ospedale Sant Orsola Malpighi /ID# 155611
🇮🇹Bologna, Emilia-Romagna, Italy
ASST Rhodense/Presidio Ospedaliero di Rho /ID# 211449
🇮🇹Rho, Milano, Italy
Istituto Clinico Humanitas /ID# 155610
🇮🇹Rozzano, Milano, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 158018
🇮🇹Rome, Roma, Italy
A.O. Per L'Emergenza Cannizzaro /ID# 164036
🇮🇹Catania, Italy
ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 155607
🇮🇹Milano, Italy
ASST Grande Ospedale Metropolitano Niguarda /ID# 170947
🇮🇹Milano, Italy
Azienda Ospedaliero-Universitaria di Modena /ID# 201819
🇮🇹Modena, Italy
UOC Medicina Interna e Gastroe /ID# 155608
🇮🇹Rome, Italy
CHU Montpellier - Hôpital Saint Eloi /ID# 223779
🇫🇷Montpellier Cedex 5, Herault, France
Universitaetsklinikum Ulm /ID# 164992
🇩🇪Ulm, Baden-Wuerttemberg, Germany
Hospital Universitario de Salamanca /ID# 159446
🇪🇸Salamanca, Spain
Lenus Research & Medical Group /ID# 169730
🇺🇸Sweetwater, Florida, United States
DM Clinical Research/Southwest /ID# 165012
🇺🇸Oak Lawn, Illinois, United States
Cleveland Clinic Main Campus /ID# 209232
🇺🇸Cleveland, Ohio, United States
Universitaetsklinikum Freiburg /ID# 162034
🇩🇪Freiburg, Baden-Wuerttemberg, Germany
Universitaetsklinikum Koeln /ID# 164991
🇩🇪Köln, Nordrhein-Westfalen, Germany
Clinical Associates in Research Therapeutics of America, LLC /ID# 161376
🇺🇸San Antonio, Texas, United States
Southern Star Research Institute, LLC /ID# 168776
🇺🇸San Antonio, Texas, United States
Houma Digestive Health Special /ID# 158317
🇺🇸Houma, Louisiana, United States
Clin Res Inst of Michigan, LLC /ID# 160327
🇺🇸Chesterfield, Michigan, United States
Cemic /Id# 167782
🇦🇷Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
University General Hospital of Heraklion PA.G.N.I /ID# 165216
🇬🇷Heraklion, Kriti, Greece
University of Calgary /ID# 169111
🇨🇦Calgary, Alberta, Canada
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 164251
🇯🇵Sapporo-shi, Hokkaido, Japan
St. Marianna University Hospital /ID# 226728
🇯🇵Kawasaki-shi, Kanagawa, Japan
Yamagata University Hospital /ID# 171474
🇯🇵Yamagata-shi, Yamagata, Japan
Centrum Medyczne Plejady /ID# 170633
🇵🇱Krakow, Malopolskie, Poland
Kitasato University Kitasato Institute Hospital /ID# 164256
🇯🇵Minato-ku, Tokyo, Japan
Showa University Fujigaoka Hospital /ID# 209555
🇯🇵Yokohama-shi, Kanagawa, Japan
Japanese Red Cross Wakayama Medical Center /ID# 171195
🇯🇵Wakayama-shi, Wakayama, Japan
Wakayama Medical University Hospital /ID# 169487
🇯🇵Wakayama-shi, Wakayama, Japan
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 170714
🇱🇹Kaunas, Lithuania
Ponce Medical School Foundation /ID# 221244
🇵🇷Ponce, Puerto Rico
Interdisctrict Multidisciplinary Hospital /ID# 203335
🇷🇺Anzorey, Kabardino-Balkarskaya Respublika, Russian Federation
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171293
🇹🇷Istanbul, Turkey
Royal Devon University Healthcare NHS Foundation Trust /ID# 157587
🇬🇧Exeter, Devon, United Kingdom
University Hospital Southampton NHS Foundation Trust /ID# 210813
🇬🇧Southampton, Hampshire, United Kingdom
NZOZ Vivamed Jadwiga Miecz /ID# 216307
🇵🇱Warszawa, Mazowieckie, Poland
Centro Hosp de Tondela-Viseu /ID# 166053
🇵🇹Viseu, Portugal
Yale Univ Digestive Diseases /ID# 213179
🇺🇸New Haven, Connecticut, United States
Omega Research Group /ID# 203059
🇺🇸Orlando, Florida, United States
Advent Health /ID# 160433
🇺🇸Orlando, Florida, United States
Delricht Research /ID# 206815
🇺🇸New Orleans, Louisiana, United States
Mayo Clinic - Rochester /ID# 200458
🇺🇸Rochester, Minnesota, United States
Quality Clinical Research Inc. /ID# 167313
🇺🇸Omaha, Nebraska, United States
UCSF Center for Colitis and Crohn's Disease /ID# 201210
🇺🇸San Francisco, California, United States
AdventHealth Tampa /ID# 170503
🇺🇸Tampa, Florida, United States
Endoscopic Research, Inc. /ID# 206711
🇺🇸Orlando, Florida, United States
Clinical Research Trials of Florida, Inc. /ID# 201783
🇺🇸Tampa, Florida, United States
Robley Rex VA Medical Center /ID# 218648
🇺🇸Louisville, Kentucky, United States
Nola Research Works, LLC /ID# 161368
🇺🇸New Orleans, Louisiana, United States
Digestive Disease Specialists /ID# 170779
🇺🇸Oklahoma City, Oklahoma, United States
Vanderbilt University Medical Center /ID# 160580
🇺🇸Nashville, Tennessee, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 158524
🇺🇸Ann Arbor, Michigan, United States
Great Lakes Gastroenterology Research, LLC /ID# 201777
🇺🇸Mentor, Ohio, United States
Southern California Res. Ctr. /ID# 169660
🇺🇸Coronado, California, United States
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