A Multicenter, Randomized, Double-Blind, Placebo Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Ulcerative Colitis
- Conditions
- Ulcerative Colitis (UC)
- Interventions
- Registration Number
- NCT03398148
- Lead Sponsor
- AbbVie
- Brief Summary
The objectives of Sub-Study 1 are to evaluate the efficacy, safety, and pharmacokinetics of risankizumab as induction treatment in subjects with moderately to severely active ulcerative colitis (UC), and to identify the appropriate induction dose of risankizumab for further evaluation in Sub-Study 2.
The objective of Sub-Study 2 is to evaluate the efficacy and safety of risankizumab compared to placebo in inducing clinical remission in subjects with moderately to severely active UC.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1558
- Male or female aged >=18 to <= 80 years at the Baseline Visit. Where locally permissible, subjects 16 to < 18 years of age who meet the definition of Tanner stage 5 for development at the Baseline Visit.
- Confirmed diagnosis of ulcerative colitis (UC) for at least 3 months prior to Baseline.
- Active UC as assessed by Adapted Mayo Score and Endoscopic Subscore.
- Demonstrated intolerance or inadequate response to conventional therapy and tofacitinib (not a biologic) and one or more biologic therapies.
- Females must be postmenopausal for more than 1 year or surgically sterile or practicing specific forms of birth control.
- Participant with a current diagnosis of Crohn's disease (CD), inflammatory bowel disease-unclassified (IBD-U) or a history of radiation colitis or ischemic colitis.
- Participant receiving prohibited medications and treatment.
- Extent of inflammatory disease limited to the rectum as assessed by screening endoscopy.
- Participant with currently known complications of UC (e.g., megacolon).
- No known active Coronavirus Disease - 2019 (COVID-19) infection.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Substudy 1, Induction Period 1: Double-blind Placebo IV placebo for risankizumab Participants randomized to receive placebo for risankizumab administered by intravenous (IV) infusion. Substudy 1, Induction Period 1: Double-blind Risankizumab 600mg IV risankizumab IV Participants randomized to receive risankizumab 600mg administered by intravenous (IV) infusion. Substudy 1, Induction Period 1: Double-blind Risankizumab 1200mg IV risankizumab IV Participants randomized to receive risankizumab 1200mg administered by intravenous (IV) infusion. Substudy 1, Induction Period 1: Double-blind Risankizumab 1800mg IV risankizumab IV Participants randomized to receive risankizumab 1800mg administered by intravenous (IV) infusion. Substudy 1, Induction Period 1: Open-label Risankizumab 1800mg IV risankizumab IV Participants receive risankizumab 1800mg administered by intravenous (IV) infusion. Substudy 1, Induction Period 2: Double-blind Risankizumab 180mg SC risankizumab SC Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab 180mg administered by subcutaneous (SC) injection in Induction 2. Substudy 1, Induction Period 2: Double-blind Risankizumab 360mg SC risankizumab SC Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab 360mg administered by subcutaneous (SC) injection in Induction 2. Substudy 1, Induction Period 2: Double-blind Risankizumab 1800mg IV risankizumab IV Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab 1800mg administered by intravenous (IV) infusion in Induction 2. Substudy 1, Induction Period 2: Double-blind Risankizumab 1800mg IV Pbo risankizumab IV Participants who received placebo with inadequate response in Induction 1 receive risankizumab 1800mg administered by intravenous (IV) infusion in Induction 2. Substudy 2, Induction Period 1: Double-blind Placebo IV placebo for risankizumab Participants randomized to receive placebo for risankizumab administered by intravenous (IV) infusion. Substudy 2, Induction Period 1: Double-blind Risankizumab 1200mg IV risankizumab IV Participants randomized to receive risankizumab 1200mg administered by intravenous (IV) infusion. Substudy 2, Induction Period 2: Double-blind Risankizumab 180mg SC risankizumab SC Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab 180mg administered by subcutaneous (SC) injection in Induction 2. Substudy 2, Induction Period 2: Double-blind Risankizumab 360mg SC risankizumab SC Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab 360mg administered by subcutaneous (SC) injection in Induction 2. Substudy 2, Induction Period 2: Double-blind Risankizumab 1200mg IV risankizumab IV Participants who received risankizumab with inadequate response in Induction 1 randomized to receive risankizumab 1200mg administered by intravenous (IV) infusion in Induction 2. Substudy 2, Induction Period 2: Double-blind Risankizumab 1200mg IV Pbo risankizumab IV Participants who received placebo with inadequate response in Induction 1 randomized to receive risankizumab 1200mg administered by intravenous (IV) infusion in Induction 2.
- Primary Outcome Measures
Name Time Method Sub-Study 1: Percentage of Participants Achieving Clinical Remission Per Adapted Mayo Score Week 12 The Adapted Mayo Score is a composite score of UC disease activity based on the following 3 subscores:
1. Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal)
2. Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed)
3. Endoscopic subscore, scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration)
The overall Adapted Mayo score ranges from 0 to 9 where higher scores represent more severe disease.
For Sub-Study 1, clinical remission was defined as SFS ≤ 1, and not greater than baseline, RBS of 0, and endoscopic subscore ≤ 1.Sub-Study 2: Percentage of Participants Achieving Clinical Remission Per Adapted Mayo Score Week 12 The Adapted Mayo Score is a composite score of UC disease activity based on the following 3 subscores:
1. Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal)
2. Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed)
3. Endoscopic subscore, scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration)
The overall Adapted Mayo score ranges from 0 to 9 where higher scores represent more severe disease.
For Sub-Study 2, clinical remission was defined as SFS ≤ 1, and not greater than baseline, RBS of 0, and endoscopic subscore ≤ 1. Evidence of friability during endoscopy in subjects with otherwise "mild" endoscopic activity will confer an endoscopic subscore of 2.
- Secondary Outcome Measures
Name Time Method Sub-Study 1: Percentage of Participants Achieving Endoscopic Improvement Week 12 Endoscopic improvement is defined as endoscopy subscore of 0 or 1.
Endoscopies were assessed by a blinded central reader and scored according to the following scale: 0 = Normal or inactive disease; 1 = Mild disease (erythema, decreased vascular pattern); 2 = Moderate disease (marked erythema, lack of vascular pattern, any friability, erosions); 3 = Severe disease (spontaneous bleeding, ulceration).Sub-Study 1: Percentage of Participants Achieving Clinical Remission Per Full Mayo Score in Participants With a Full Mayo Score of 6 to 12 at Baseline Week 12 The Mayo score is a tool designed to measure disease activity for ulcerative colitis. The Full Mayo score (FMS) ranges from 0 (normal or inactive disease) to 12 (severe disease) and is calculated as the sum of 4 subscores (stool frequency, rectal bleeding, endoscopy \[confirmed by a central reader\], and physician's global assessment), each of which ranges from 0 (normal) to 3 (severe disease). Negative changes indicate improvement.
Clinical remission per FMS is defined as Mayo Score ≤ 2 and no individual subscore \> 1.Sub-Study 1: Percentage of Participants Achieving Clinical Response Per Adapted Mayo Score Week 12 The Adapted Mayo Score is a composite score of UC disease activity based on the following 3 subscores:
1. Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal)
2. Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed)
3. Endoscopic subscore, scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration)
The overall Adapted Mayo Score ranges from 0 to 9 where higher scores represent more severe disease.
Clinical response per Adapted Mayo Score was defined as decrease from baseline in Adapted Mayo Score ≥ 2 points and ≥ 30%, plus a decrease in RBS ≥ 1 or an absolute RBS ≤ 1.Sub-Study 1: Percentage of Participants Achieving Clinical Response Per Partial Adapted Mayo Score Week 4 Clinical response per Partial Adapted Mayo Score (without endoscopy).
The Partial Mayo Score is a composite score of UC disease activity based on the following 2 subscores:
1. Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal)
2. Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed)
The overall Partial Mayo Score ranges from 0 to 6 with higher scores representing more severe disease.
Clinical response per Partial Mayo Score is defined as a decrease in Partial Adapted Mayo score \>= 1 points and ≥ 30% from Baseline, plus a decrease in RBS ≥ 1 or an absolute RBS ≤ 1.Sub-Study 1: Percentage of Participants Achieving Endoscopic Remission Week 12 Endoscopic remission was defined as endoscopy subscore of 0.
Sub-Study 1: Percentage of Participants With Hospitalization Through Week 12 Participants with an event that results in admission to the hospital.
Sub-Study 1: Percentage of Participants Achieving Histologic Endoscopic Mucosal Remission (HEMR) Week 12 Mucosal healing defined as endoscopic and histologic remission.
Mucosal healing is defined as an endoscopic score of 0 and Geboes score \< 2.0. The endoscopic subscore ranges from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration).
The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.Sub-Study 1: Change in Ulcerative Colitis Symptom Questionnaire (UC-SQ) Baseline Through Week 12 The US-SQ is a patient questionnaire to assess severity of Ulcerative Colitis (UC) related gastrointestinal symptoms (e.g., frequent bowel movements, abdominal pain, cramping) and non-gastrointestinal symptoms (e.g., joint pain and sleep difficulties).
It consists of 17 questions and each question is answered on a scale from can be answered on a scale from 1 (Not at all/ never) to 5 (Very much/Always) with overall symptom score range from 17 to 85. A lower score indicates lower UC severity.Sub-Study 2: Percentage of Participants Achieving No Abdominal Pain Week 12 Percentage of participants who reported no abdominal pain. Abdominal pain was assessed by participants in a subject diary completed once a day.
Sub-Study 1: Change in Inflammatory Bowel Disease Questionnaire (IBDQ) Baseline Through Week 12 The IBDQ is used to assess the quality of life of patients with inflammatory bowel disease.
The IBDQ is a 32-item (ranges 1 - 7) self-report questionnaire for patients with IBD to evaluate the patient reported outcomes across 4 dimensions: bowel symptoms (loose stools, abdominal pain), systemic symptoms (fatigue, altered sleep pattern), social function (work attendance, need to cancel social events), and emotional function (anger, depression, irritability).
The IBDQ total Score ranges from 32 to 224 with a higher score indicating better outcome.Sub-Study 1: Change From Baseline in Short Form-36 (SF-36) - Physical Component Baseline Through Week 12 The SF-36 (Version 2) is a self-administered, health-related survey that measures the impact of disease on overall quality of life during the past 4 weeks. SF-36 consists of 36 questions covering 8 health domains: physical functioning, bodily pain, role limitations due to physical problems and emotional problems, general health, mental health, social functioning, vitality, and 2 component scores (mental \[MCS\] and physical \[PCS\]). MCS consisted of social functioning, vitality, mental health, and role-emotional scales. PCS consisted of physical functioning, bodily pain, role-physical, and general health scales. Each domain is scored by summing the individual items and transforming the scores into a 0 (poorest health) to 100 (best health) scale with higher scores indicating better health status or functioning.
Sub-Study 1: Change From Baseline in Short Form-36 (SF-36) - Mental Component Baseline through Week 12 The SF-36 (Version 2) is a self-administered, health-related survey that measures the impact of disease on overall quality of life during the past 4 weeks. SF-36 consists of 36 questions covering 8 health domains: physical functioning, bodily pain, role limitations due to physical problems and emotional problems, general health, mental health, social functioning, vitality, and 2 component scores (mental \[MCS\] and physical \[PCS\]). MCS consisted of social functioning, vitality, mental health, and role-emotional scales. PCS consisted of physical functioning, bodily pain, role-physical, and general health scales. Each domain is scored by summing the individual items and transforming the scores into a 0 (poorest health) to 100 (best health) scale with higher scores indicating better health status or functioning.
Sub-Study 1: Change in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Baseline Through Week 12 The FACIT-Fatigue Scale is a validated self-administered 13-item tool that measures an individual's level of fatigue during their usual daily activities over the past 7 days. Each of the fatigue and impact of fatigue items are measured on a four-point Likert scale.
0 = not at all
1. = a little bit
2. = somewhat
3. = quite a bit
4. = very much
The FACIT Fatigue Scale is the sum of the individual 13 scores and ranges from 0 to 52 where higher scores indicate better the quality of life. A positive change from baseline indicates improvement.Sub-Study 1: Percentage of Participants Undergoing Ulcerative Colitis (UC)-Related Surgeries Through Week 12 Participants who underwent surgery related to UC.
Sub-Study 2: Percentage of Participants Achieving Clinical Response Per Adapted Mayo Score Week 12 The Adapted Mayo Score is a composite score of UC disease activity based on the following 3 subscores:
1. Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal)
2. Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed)
3. Endoscopic subscore, scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration)
The overall Adapted Mayo Score ranges from 0 to 9 where higher scores represent more severe disease.
Clinical Response is defined as a decrease from baseline in the Adapted Mayo Score ≥ 2 points and ≥ 30% from baseline, and a decrease in RBS ≥ 1 or an absolute RBS ≤ 1).Sub-Study 2: Percentage of Participants Achieving Endoscopic Improvement Week 12 Endoscopic Improvement is defined as an endoscopic subscore of 0 or 1.
Endoscopies were assessed by a blinded central reader and scored according to the following scale: 0 = Normal or inactive disease; 1 = Mild disease (erythema, decreased vascular pattern); 2 = Moderate disease (marked erythema, lack of vascular pattern, any friability, erosions); 3 = Severe disease (spontaneous bleeding, ulceration).Sub-Study 2: Percentage of Participants Achieving Histologic Endoscopic Mucosal Improvement (HEMI) Week 12 Histologic-Endoscopic Mucosal Improvement is defined as an endoscopic subscore of 0 or 1 without evidence of friability and a Geboes score ≤ 3.1.
The endoscopic subscore ranges from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration).
The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers).
The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.Sub-Study 2: Percentage of Participants Achieving Endoscopic Remission Week 12 Endoscopic remission per endoscopy subscore.
Endoscopic Remission: endoscopic subscore = 0.Sub-Study 2: Percentage of Participants Achieving Clinical Response Per Partial Adapted Mayo Score at Week 4 Week 4 Clinical response per Partial Adapted Mayo Score (without endoscopy).
The Partial Mayo Score is a composite score of UC disease activity based on the following 2 subscores:
1. Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal)
2. Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed)
The overall Partial Mayo Score ranges from 0 to 6 with higher scores representing more severe disease.
Clinical Response per Partial Mayo Score is defined as a decrease in Partial Adapted Mayo Score ≥ 1 points and ≥ 30% from Baseline, plus a decrease in RBS ≥ 1 or an absolute RBS ≤ 1.Sub-Study 2: Percentage of Participants Achieving No Bowel Urgency Week 12 Percentage of participants who reported no bowel urgency. Bowel urgency was assessed by participants in a subject diary completed once a day.
Sub-Study 2: Percentage of Participants Achieving Histologic Endoscopic Mucosal Remission (HEMR): Endoscopy Subscore of 0 and Geboes Score < 2.0) at Week 12 Week 12 Mucosal healing defined as endoscopic and histologic remission.
Mucosal healing is defined as an endoscopic score of 0 and Geboes score \< 2.0. The endoscopic subscore ranges from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration).
The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.Sub-Study 2: Change in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Baseline to Week 12 The FACIT-Fatigue Scale is a validated self-administered 13-item tool that measures an individual's level of fatigue during their usual daily activities over the past 7 days. Each of the fatigue and impact of fatigue items are measured on a four-point Likert scale.
0 = not at all
1. = a little bit
2. = somewhat
3. = quite a bit
4. = very much
The FACIT Fatigue Scale is the sum of the individual 13 scores and ranges from 0 to 52 where higher scores indicate better the quality of life. A positive change from baseline indicates improvement.Sub-Study 2: Change in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score Baseline to Week 12 The IBDQ is used to assess the quality of life of patients with inflammatory bowel disease.
The IBDQ is a 32-item (ranges 1 - 7) self-report questionnaire for patients with IBD to evaluate the patient reported outcomes across 4 dimensions: bowel symptoms (loose stools, abdominal pain), systemic symptoms (fatigue, altered sleep pattern), social function (work attendance, need to cancel social events), and emotional function (anger, depression, irritability).
The IBDQ total Score ranges from 32 to 224 with a higher score indicating better outcome.Sub-Study 2: Occurrence of UC-related Hospitalizations Baseline Through Week 12 Participants with an UC-related event that results in admission to the hospital.
Sub-Study 2: Percentage of Participants Achieving No Nocturnal Bowel Movements Week 12 Percentage of participants who reported no nocturnal bowel movements.
Sub-Study 2: Percentage of Participants Achieving No Tenesmus Week 12 Percentage of participants who reported no tenesmus.
Sub-Study 2: Change in Number of Fecal Incontinence Episodes Per Week Baseline to Week 12 Change in number of fecal incontinence episodes per week.
Sub-Study 2: Change in Number of Days Per Week With Sleep Interrupted Due to UC Symptoms Baseline to Week 12 Change from baseline in number of days per week with sleep interrupted due to UC symptoms.
Trial Locations
- Locations (430)
Louisana Research Center, LLC /ID# 201204
🇺🇸Shreveport, Louisiana, United States
Massachusetts General Hospital - Crohn's and Colitis Center /ID# 164255
🇺🇸Boston, Massachusetts, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 158524
🇺🇸Ann Arbor, Michigan, United States
Clin Res Inst of Michigan, LLC /ID# 160327
🇺🇸Chesterfield, Michigan, United States
Mayo Clinic - Rochester /ID# 200458
🇺🇸Rochester, Minnesota, United States
Quality Clinical Research Inc. /ID# 167313
🇺🇸Omaha, Nebraska, United States
Weill Cornell Medicine /ID# 165887
🇺🇸New York, New York, United States
Columbia Univ Medical Center /ID# 161934
🇺🇸New York, New York, United States
Lenox Hill Hospital /ID# 168470
🇺🇸New York, New York, United States
Manhattan Clinical Research, LLC /ID# 211805
🇺🇸New York, New York, United States
DiGiovanna Institute for Medical Education & Research /ID# 171129
🇺🇸North Massapequa, New York, United States
University of Rochester Medical Center /ID# 161664
🇺🇸Rochester, New York, United States
Atrium Health Carolinas Medical Center /ID# 158512
🇺🇸Charlotte, North Carolina, United States
Carolina Research /ID# 201090
🇺🇸Greenville, North Carolina, United States
Plains Clinical Research Center, LLC /ID# 169732
🇺🇸Fargo, North Dakota, United States
Cleveland Clinic Main Campus /ID# 209232
🇺🇸Cleveland, Ohio, United States
The Ohio State University /ID# 164714
🇺🇸Columbus, Ohio, United States
Optimed Research, Ltd. /ID# 167113
🇺🇸Columbus, Ohio, United States
Great Lakes Gastroenterology Research, LLC /ID# 201777
🇺🇸Mentor, Ohio, United States
ProMedica Physicians Digestive Healthcare /ID# 215623
🇺🇸Sylvania, Ohio, United States
Digestive Disease Specialists /ID# 170779
🇺🇸Oklahoma City, Oklahoma, United States
Adult Gastroenterology Associates - Gen 1 Research /ID# 208867
🇺🇸Tulsa, Oklahoma, United States
Penn State Milton S. Hershey Medical Center /ID# 223563
🇺🇸Hershey, Pennsylvania, United States
University of Pennsylvania /ID# 166266
🇺🇸Philadelphia, Pennsylvania, United States
Digestive Disease Associates, LTD /ID# 232407
🇺🇸Wyomissing, Pennsylvania, United States
Gastroenterology Associates, P.A. of Greenville /ID# 160472
🇺🇸Greenville, South Carolina, United States
Gastro One /ID# 160418
🇺🇸Cordova, Tennessee, United States
East Tennessee Research Institute /ID# 168747
🇺🇸Johnson City, Tennessee, United States
Vanderbilt University Medical Center /ID# 160580
🇺🇸Nashville, Tennessee, United States
Inquest Clinical Research /ID# 165685
🇺🇸Baytown, Texas, United States
Texas Digestive Disease Consultants /ID# 209950
🇺🇸Cedar Park, Texas, United States
GI Alliance /ID# 209798
🇺🇸Cedar Park, Texas, United States
DHAT Research Institute /ID# 158226
🇺🇸Garland, Texas, United States
Vilo Research Group Inc /ID# 207656
🇺🇸Houston, Texas, United States
CliniCore International, LLC /ID# 158218
🇺🇸Houston, Texas, United States
Baylor College of Medicine - Baylor Medical Center /ID# 158221
🇺🇸Houston, Texas, United States
Precision Research Institute, LLC /ID# 201351
🇺🇸Houston, Texas, United States
Centex Studies, Inc. - Houston /ID# 201222
🇺🇸Houston, Texas, United States
Caprock Gastro Research, LLC /ID# 215432
🇺🇸Lubbock, Texas, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 161376
🇺🇸San Antonio, Texas, United States
Southern Star Research Institute, LLC /ID# 168776
🇺🇸San Antonio, Texas, United States
Baylor Scott & White Center for Diagnostic Medicine /ID# 204130
🇺🇸Temple, Texas, United States
Tyler Research Institute, LLC /ID# 166800
🇺🇸Tyler, Texas, United States
Gastro Health & Nutrition - Victoria /ID# 164321
🇺🇸Victoria, Texas, United States
Advanced Research Institute /ID# 160480
🇺🇸Ogden, Utah, United States
Gastroenterology Consultants of Southwest Virginia /ID# 218143
🇺🇸Roanoke, Virginia, United States
Virginia Mason Medical Center /ID# 160466
🇺🇸Seattle, Washington, United States
Gedyt /ID# 243423
🇦🇷Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
Cemic /Id# 167782
🇦🇷Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
Hospital Provincial del Centenario /ID# 170898
🇦🇷Rosario, Santa Fe, Argentina
Sanatorio 9 de Julio /ID# 167780
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Hospital Privado Univesitario /ID# 167779
🇦🇷Cordoba, Argentina
Duplicate_Universitaetsklinikum St.Poelten /ID# 169048
🇦🇹St. Poelten, Niederoesterreich, Austria
Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 215320
🇦🇹Linz, Oberoesterreich, Austria
Medizinische Universitaet Graz /ID# 169053
🇦🇹Graz, Steiermark, Austria
Medizinische Universitaet Wien /ID# 169050
🇦🇹Vienna, Wien, Austria
Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 200685
🇦🇹Salzburg, Austria
Cliniques Universitaires de Bruxelles Hopital Erasme /ID# 200252
🇧🇪Brussels, Bruxelles-Capitale, Belgium
UCL Saint-Luc /ID# 200039
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
CHU UCL Namur - site Godinne /ID# 200254
🇧🇪Godinne, Namur, Belgium
Universitair Ziekenhuis Leuven /ID# 170812
🇧🇪Leuven, Vlaams-Brabant, Belgium
AZ-Delta /ID# 200040
🇧🇪Roeselare, West-Vlaanderen, Belgium
Imelda Ziekenhuis /ID# 211100
🇧🇪Bonheiden, Belgium
CHU de Liege /ID# 200253
🇧🇪Liege, Belgium
Groupe Sante CHC - Clinique du MontLegia /ID# 200250
🇧🇪Liege, Belgium
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 157679
🇧🇷Goiânia, Goias, Brazil
Hospital Nossa Senhora das Graças /ID# 157671
🇧🇷Curitiba, Parana, Brazil
Hospital de Clinicas de Porto Alegre /ID# 157662
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Upeclin Fmb - Unesp /Id# 157690
🇧🇷Botucatu, Sao Paulo, Brazil
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 157660
🇧🇷Ribeirão Preto, Sao Paulo, Brazil
Faculdade de Medicina do ABC /ID# 163995
🇧🇷Santo André, Sao Paulo, Brazil
Kaiser Clinica e Hospital Dia /ID# 157680
🇧🇷Sao Jose Do Rio Preto, Sao Paulo, Brazil
UMHAT Kaspela EOOD /ID# 200797
🇧🇬Plovdiv, Bulgaria
MHAT Hadzhi Dimitar /ID# 207945
🇧🇬Sliven, Bulgaria
Second MHAT Sofia /ID# 200799
🇧🇬Sofia, Bulgaria
UMHAT Sveti Ivan Rilski /ID# 210797
🇧🇬Sofia, Bulgaria
UMHAT Tsaritsa Joanna - ISUL /ID# 209977
🇧🇬Sofia, Bulgaria
University of Calgary /ID# 169111
🇨🇦Calgary, Alberta, Canada
Allen Whey Khye Lim Professional Corporation /ID# 169767
🇨🇦Edmonton, Alberta, Canada
Covenant Health /ID# 169114
🇨🇦Edmonton, Alberta, Canada
Fraser Clinical Trials Inc /ID# 169102
🇨🇦New Westminster, British Columbia, Canada
Percuro Clinical Research, Ltd /ID# 169109
🇨🇦Victoria, British Columbia, Canada
London Health Sciences Center- University Hospital /ID# 169103
🇨🇦London, Ontario, Canada
Scott Shulman Medicine Professional Corporation /ID# 169113
🇨🇦North Bay, Ontario, Canada
Toronto Digestive Disease Asso /ID# 169106
🇨🇦Vaughan, Ontario, Canada
Hotel Dieu de Levis /ID# 214378
🇨🇦Lévis, Quebec, Canada
CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 169108
🇨🇦Montreal, Quebec, Canada
Royal Victoria Hospital / McGill University Health Centre /ID# 169104
🇨🇦Montreal, Quebec, Canada
Servicio de Salud Araucanía Norte Hospital Victoria /ID# 213151
🇨🇱Victoria, Araucania, Chile
Complejo Asistencial Dr. Sotero del Rio /ID# 169385
🇨🇱Santiago, Region Metropolitana Santiago, Chile
Servicio de Salud Occidente Hospital San Juan de Dios /ID# 171125
🇨🇱Santiago, Region Metropolitana Santiago, Chile
Hospital Guillermo Grant Benavente de Concepción /ID# 210761
🇨🇱Concepción, Chile
Hospital Las Higueras /ID# 167093
🇨🇱Talcahuano, Chile
The First Affiliated Hospital of Anhui Medical University /ID# 211228
🇨🇳Hefei, Anhui, China
Beijing Friendship Hospital /ID# 211066
🇨🇳Beijing, Beijing, China
The Sixth Affiliated Hosp Sun /ID# 211231
🇨🇳Guangzhou, Guangdong, China
The Second Hospital of Hebei Medical University /ID# 213018
🇨🇳Shijiazhuang, Hebei, China
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 211071
🇨🇳Wuhan, Hubei, China
Tongji Hospital Tongji Medical College of HUST /ID# 211072
🇨🇳Wuhan, Hubei, China
Renmin Hospital of Wuhan University /ID# 212868
🇨🇳Wuhan, Hubei, China
Huai'an First People's Hospital /ID# 239196
🇨🇳Huaian, Jiangsu, China
Nanjing Drum Tower Hospital /ID# 227439
🇨🇳Nanjing, Jiangsu, China
Jiangsu Province Hospital /ID# 211232
🇨🇳Nanjing, Jiangsu, China
Wuxi People's Hospital /ID# 218798
🇨🇳Wuxi, Jiangsu, China
The First Affiliated Hospital of Nanchang University /ID# 212183
🇨🇳Nanchang, Jiangxi, China
The First Hospital of Jilin University /ID# 212278
🇨🇳Changchun, Jilin, China
General Hospital of Ningxia Medical University /ID# 213911
🇨🇳Yinchuan City, Ningxia, China
Xijing Hospital /ID# 211639
🇨🇳Xi'an, Shaanxi, China
Tangdu Hospital of The Fourth Military Medical University, PLA /ID# 215504
🇨🇳Xi'an, Shaanxi, China
Shanghai East Hospital /ID# 218791
🇨🇳Pudong New District, Shanghai, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210962
🇨🇳Shanghai, Shanghai, China
Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 211233
🇨🇳Shanghai, Shanghai, China
Shanghai General Hospital /ID# 226190
🇨🇳Shanghai, Shanghai, China
West China Hospital, Sichuan University /ID# 211276
🇨🇳Chengdu, Sichuan, China
The second Affiliated hospital of Zhejiang University school of Medicine /ID# 211025
🇨🇳Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 211064
🇨🇳Hangzhou, Zhejiang, China
The Second Xiangya Hospital of Central South University /ID# 211198
🇨🇳Changsha, China
Shengjing Hospital of China Medical University /ID# 211646
🇨🇳Shenyang, China
Oncomédica SAS /ID# 206937
🇨🇴Monteria, Cordoba, Colombia
Hospital Universitario San Vic /ID# 171490
🇨🇴Medellin, Colombia
Clinical Hospital Dubrava /ID# 157475
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Zagreb /ID# 157471
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Zagreb /ID# 201917
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Osijek /ID# 157472
🇭🇷Osijek, Osjecko-baranjska Zupanija, Croatia
Klinicki bolnicki centar Split /ID# 157473
🇭🇷Split, Splitsko-dalmatinska Zupanija, Croatia
Fakultni nemocnice u sv. Anny v Brne /ID# 239157
🇨🇿Brno, Czechia
Nemocnice Ceske Budejovice a.s. /ID# 225226
🇨🇿Ceske Budejovice, Czechia
Hepato-Gastroenterologie HK, s.r.o. /ID# 163395
🇨🇿Hradec Kralove, Czechia
Fakultni nemocnice Ostrava /ID# 225567
🇨🇿Ostrava, Czechia
Bispebjerg and Frederiksberg Hospital /ID# 208945
🇩🇰Copenhagen NV, Hovedstaden, Denmark
Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 202266
🇩🇰Hvidovre, Hovedstaden, Denmark
Sjællands Universitetshospital /ID# 200033
🇩🇰Roskilde, Sjælland, Denmark
Odense University Hospital /ID# 205602
🇩🇰Odense C, Syddanmark, Denmark
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 200848
🇪🇬Alexandria, Egypt
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 226793
🇪🇬Alexandria, Egypt
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 226794
🇪🇬Alexandria, Egypt
Air Force Specialized Hospital /ID# 170986
🇪🇬Cairo, Egypt
National Liver Institute /ID# 171040
🇪🇬Menoufiya, Egypt
Chu de Nice-Hopital L'Archet Ii /Id# 171577
🇫🇷Nice, Alpes-Maritimes, France
APHM - Hopital Nord /ID# 225825
🇫🇷Marseille, Bouches-du-Rhone, France
CHU Bordeaux - Hopital Haut Leveque /ID# 171579
🇫🇷Pessac, Gironde, France
CHU Montpellier - Hôpital Saint Eloi /ID# 223779
🇫🇷Montpellier Cedex 5, Herault, France
Hopital Beaujon /ID# 200092
🇫🇷Clichy, Ile-de-France, France
Centre Médico Chirurgical Ambroise Paré Hartmann /ID# 249860
🇫🇷Neuilly Sur Seine, Ile-de-France, France
CHU de SAINT ETIENNE - Hopital Nord /ID# 171580
🇫🇷St. Priest En Jarez, Loire, France
CHRU Nancy - Hopitaux de Brabois /ID# 200095
🇫🇷Vandoeuvre-les-Nancy, Meurthe-et-Moselle, France
CHU Amiens-Picardie Site Sud /ID# 171576
🇫🇷Amiens CEDEX 1, Somme, France
Clinique Jules Verne /ID# 240976
🇫🇷Nantes, France
Universitaetsklinikum Freiburg /ID# 162034
🇩🇪Freiburg, Baden-Wuerttemberg, Germany
Praxis fuer Gastroenterologie /ID# 166152
🇩🇪Heidelberg, Baden-Wuerttemberg, Germany
Universitatsklinikum Mannheim /ID# 162035
🇩🇪Mannheim, Baden-Wuerttemberg, Germany
Universitaetsklinikum Ulm /ID# 164992
🇩🇪Ulm, Baden-Wuerttemberg, Germany
Universitaetsklinikum Erlangen /ID# 159354
🇩🇪Erlangen, Bayern, Germany
Praxiszentrum fuer Gastroenterologie /ID# 219069
🇩🇪Grevenbroich, Nordrhein-Westfalen, Germany
Universitaetsklinikum Koeln /ID# 164991
🇩🇪Köln, Nordrhein-Westfalen, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159360
🇩🇪Kiel, Schleswig-Holstein, Germany
Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 219145
🇩🇪Berlin, Germany
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159361
🇩🇪Berlin, Germany
Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 210510
🇩🇪Berlin, Germany
DRK Kliniken Berlin Westend /ID# 166153
🇩🇪Berlin, Germany
Stadtisches Klinikum Braunschweig /ID# 163687
🇩🇪Braunschweig, Germany
Agaplesion Markus Krankenhaus /ID# 159356
🇩🇪Frankfurt am Main, Germany
Gastroenterologie Opernstrasse /ID# 163683
🇩🇪Kassel, Germany
EUGASTRO GmbH /ID# 219070
🇩🇪Leipzig, Germany
Klinikum Lueneburg /ID# 163685
🇩🇪Lueneburg, Germany
Gastroenterologische Gemeinschaftspraxis Minden /ID# 162033
🇩🇪Minden, Germany
LMU Klinikum Campus Grosshadern /ID# 210481
🇩🇪München, Germany
Universitaetsklinikum Regensburg /ID# 163686
🇩🇪Regensburg, Germany
General Hospital of Athens Ippokratio /ID# 229189
🇬🇷Athens, Attiki, Greece
General Hospital of Athens Laiko /ID# 206440
🇬🇷Athens, Attiki, Greece
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 170915
🇬🇷Athens, Attiki, Greece
Tzaneio general hospital of Piraeus /ID# 206439
🇬🇷Piraeus, Attiki, Greece
University General Hospital of Heraklion PA.G.N.I /ID# 165216
🇬🇷Heraklion, Kriti, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 217480
🇬🇷Athens, Greece
General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 165218
🇬🇷Pireaus, Greece
Theageneio Anticancer Hospital /ID# 165217
🇬🇷Thessaloniki, Greece
Soroka University Medical Center /ID# 171100
🇮🇱Be'er Sheva, HaDarom, Israel
The Chaim Sheba Medical Center /ID# 211278
🇮🇱Ramat Gan, Tel-Aviv, Israel
Hadassah Medical Center-Hebrew University /ID# 171099
🇮🇱Jerusalem, Yerushalayim, Israel
Rambam Health Care Campus /ID# 171103
🇮🇱Haifa, Israel
Shaare Zedek Medical Center /ID# 163544
🇮🇱Jerusalem, Israel
Rabin Medical Center /ID# 167403
🇮🇱Petakh Tikva, Israel
University of Catanzaro /ID# 200125
🇮🇹Catanzaro, Calabria, Italy
Ospedale Sant Orsola Malpighi /ID# 155611
🇮🇹Bologna, Emilia-Romagna, Italy
Ospedale Policlinico San Martino /ID# 164031
🇮🇹Genoa, Genova, Italy
Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 163992
🇮🇹Rome, Lazio, Italy
Azienda Ospedaliera San Camillo Forlanini /ID# 155612
🇮🇹Rome, Lazio, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 171226
🇮🇹Rome, Lazio, Italy
ASST Rhodense/Presidio Ospedaliero di Rho /ID# 211449
🇮🇹Rho, Milano, Italy
Istituto Clinico Humanitas /ID# 155610
🇮🇹Rozzano, Milano, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 158018
🇮🇹Rome, Roma, Italy
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 164041
🇮🇹Negrar, Verona, Italy
A.O. Per L'Emergenza Cannizzaro /ID# 164036
🇮🇹Catania, Italy
ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 155607
🇮🇹Milano, Italy
ASST Grande Ospedale Metropolitano Niguarda /ID# 170947
🇮🇹Milano, Italy
Azienda Ospedaliero-Universitaria di Modena /ID# 201819
🇮🇹Modena, Italy
UOC Medicina Interna e Gastroe /ID# 155608
🇮🇹Rome, Italy
Aichi Medical University Hospital /ID# 164332
🇯🇵Nagakute-shi, Aichi, Japan
Nagoya City University Hospital /ID# 164331
🇯🇵Nagoya shi, Aichi, Japan
Daido Clinic /ID# 211479
🇯🇵Nagoya-shi, Aichi, Japan
Nagoya University Hospital /ID# 164271
🇯🇵Nagoya-shi, Aichi, Japan
Fujita Health University Hospital /ID# 164261
🇯🇵Toyoake-shi, Aichi, Japan
National Hospital Organization Hirosaki General Medical Center /ID# 164252
🇯🇵Hirosaki-shi, Aomori, Japan
Tokatsu Tsujinaka Hospital /ID# 164438
🇯🇵Abiko-shi, Chiba, Japan
Chiba University Hospital /ID# 209632
🇯🇵Chiba-shi, Chiba, Japan
Tsujinaka Hospital Kashiwanoha /ID# 208964
🇯🇵Kashiwa-shi, Chiba, Japan
Toho University Sakura Medical Center /ID# 164254
🇯🇵Sakura-shi, Chiba, Japan
Fukuoka University Chikushi Hospital /ID# 209055
🇯🇵Chikushino-shi, Fukuoka, Japan
Saiseikai Fukuoka Genaral Hospital /ID# 225639
🇯🇵Fukuoka-shi, Fukuoka, Japan
Fukuoka University Hospital /ID# 226189
🇯🇵Fukuoka-shi, Fukuoka, Japan
Kurume University Hospital /ID# 164427
🇯🇵Kurume-shi, Fukuoka, Japan
Gifu University Hospital /ID# 208081
🇯🇵Gifu-shi, Gifu, Japan
Ogaki Municipal Hospital /ID# 226010
🇯🇵Ogaki-shi, Gifu, Japan
National Hospital Organization Takasaki General Medical Center /ID# 164437
🇯🇵Takasaki-shi, Gunma, Japan
NHO Fukuyama Medical Center /ID# 164439
🇯🇵Fukuyama-shi, Hiroshima, Japan
Hiroshima University Hospital /ID# 164426
🇯🇵Hiroshima-shi, Hiroshima, Japan
Asahikawa Medical University Hospital /ID# 164433
🇯🇵Asahikawa-shi, Hokkaido, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 164251
🇯🇵Sapporo-shi, Hokkaido, Japan
Sapporo Medical University Hospital /ID# 164432
🇯🇵Sapporo-shi, Hokkaido, Japan
Sapporo IBD Clinic /ID# 225923
🇯🇵Sapporo-shi, Hokkaido, Japan
Sapporo Higashi Tokushukai Hospital /ID# 208488
🇯🇵Sapporo-shi, Hokkaido, Japan
Aoyama Clinic /ID# 164425
🇯🇵Kobe-shi, Hyogo, Japan
Hyogo Medical University Hospital /ID# 164424
🇯🇵Nishinomiya-shi, Hyogo, Japan
Kanazawa University Hospital /ID# 169224
🇯🇵Kanazawa-shi, Ishikawa, Japan
Sameshima Hospital /ID# 211181
🇯🇵Kagoshima-shi, Kagoshima, Japan
Tokai University Hospital /ID# 209204
🇯🇵Isehara-shi, Kanagawa, Japan
Gokeikai Ofuna Chuo Hospital /ID# 169300
🇯🇵Kamakura-shi, Kanagawa, Japan
St. Marianna University Hospital /ID# 226728
🇯🇵Kawasaki-shi, Kanagawa, Japan
Kitasato University Hospital /ID# 169226
🇯🇵Sagamihara-shi, Kanagawa, Japan
Colo-proctology Center Matsushima Clinic /ID# 225914
🇯🇵Yokohama-shi, Kanagawa, Japan
Showa University Fujigaoka Hospital /ID# 209555
🇯🇵Yokohama-shi, Kanagawa, Japan
Mie University Hospital /ID# 203633
🇯🇵Tsu-shi, Mie, Japan
Yokkaichi Hazu Medical Center /ID# 164441
🇯🇵Yokkaichi-shi, Mie, Japan
Nara Medical University Hospital /ID# 169225
🇯🇵Kashihara-shi, Nara, Japan
Kinshukai Infusion Clinic /ID# 226747
🇯🇵Osaka-shi, Osaka, Japan
Tohoku University Hospital /ID# 164430
🇯🇵Sendai-shi, Miyagi, Japan
Osaka Medical and Pharmaceutical University Hospital /ID# 226035
🇯🇵Takatsuki-shi, Osaka, Japan
Nagasaki University Hospital /ID# 202674
🇯🇵Nagasaki-shi, Nagasaki, Japan
Saga University Hospital /ID# 209396
🇯🇵Saga-shi, Saga, Japan
Tokitokai Tokito clinic /ID# 164253
🇯🇵Saitama-shi, Saitama, Japan
Tokyo Medical And Dental University Hospital /ID# 164258
🇯🇵Bunkyo-ku, Tokyo, Japan
St.Luke's International Hospital /ID# 225822
🇯🇵Chuo-ku, Tokyo, Japan
Shiga University of Medical Science Hospital /ID# 164440
🇯🇵Otsu-shi, Shiga, Japan
Hamamatsu University Hospital /ID# 226727
🇯🇵Hamamatsu-shi, Shizuoka, Japan
Matsuda Hospital /ID# 226616
🇯🇵Hamamatsu-shi, Shizuoka, Japan
NHO Shizuoka Medical Center /ID# 164435
🇯🇵Sunto-gun, Shizuoka, Japan
Teikyo University Hospital /ID# 225588
🇯🇵Itabashi-ku, Tokyo, Japan
Tokai University Hachioji Hospital /ID# 226899
🇯🇵Hachioji-shi, Tokyo, Japan
The Jikei University Hospital /ID# 164434
🇯🇵Minato-ku, Tokyo, Japan
Kitasato University Kitasato Institute Hospital /ID# 164256
🇯🇵Minato-ku, Tokyo, Japan
Kyorin University Hospital /ID# 164259
🇯🇵Mitaka-shi, Tokyo, Japan
NTT Medical Center Tokyo /ID# 225587
🇯🇵Shinagawa-ku, Tokyo, Japan
Keio University Hospital /ID# 203629
🇯🇵Shinjuku-ku, Tokyo, Japan
Japanese Red Cross Wakayama Medical Center /ID# 171195
🇯🇵Wakayama-shi, Wakayama, Japan
Wakayama Medical University Hospital /ID# 169487
🇯🇵Wakayama-shi, Wakayama, Japan
Yamagata University Hospital /ID# 171474
🇯🇵Yamagata-shi, Yamagata, Japan
Tokuyama Central Hospital /ID# 226011
🇯🇵Shunan-shi, Yamaguchi, Japan
Hanyang University Gurihospital /ID# 158702
🇰🇷Guri, Gyeonggido, Korea, Republic of
CHA University Bundang Medical Center /ID# 158710
🇰🇷Seongnam si, Gyeonggido, Korea, Republic of
The Catholic University of Korea, ST. Vincent's Hospital /ID# 158706
🇰🇷Suwon, Gyeonggido, Korea, Republic of
Kangbuk Samsung Hospital /ID# 158707
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Yonsei University Health System Severance Hospital /ID# 158701
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Inje University Haeundae Hospital /ID# 203028
🇰🇷Busan, Korea, Republic of
Dong-A University Hospital /ID# 158705
🇰🇷Busan, Korea, Republic of
Pusan National University Hospital /ID# 158711
🇰🇷Busan, Korea, Republic of
Yeungnam University Medical Center /ID# 158703
🇰🇷Daegu, Korea, Republic of
The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 242378
🇰🇷Daejeon, Korea, Republic of
Samsung Medical Center /ID# 158704
🇰🇷Seoul, Korea, Republic of
VCA Polyclinic Aura /ID# 163802
🇱🇻Riga, Latvia
Pauls Stradins Clinical University Hospital /ID# 163803
🇱🇻Riga, Latvia
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 170714
🇱🇹Kaunas, Lithuania
Vilnius University Hospital Santaros Klinikos /ID# 170614
🇱🇹Vilnius, Lithuania
Universiti Sains Malaysia /ID# 221971
🇲🇾Kelantan, Malaysia
JM Research SC /ID# 203593
🇲🇽Cuernavaca, Morelos, Mexico
Unidad de Atencion Medica e Investigacion en Salud /ID# 203595
🇲🇽Merida, Yucatan, Mexico
Health Pharma Professional Research S.A de C.V /ID# 203597
🇲🇽Del. Benito Juárez, Mexico
Academisch Medisch Centrum /ID# 157959
🇳🇱Amsterdam, Netherlands
Elisabeth Tweesteden Ziekenhuis /ID# 163767
🇳🇱Tilburg, Netherlands
Tauranga Hospital /ID# 212792
🇳🇿Tauranga South, Bay Of Plenty, New Zealand
Christchurch Hospital /ID# 205342
🇳🇿Christchurch, Canterbury, New Zealand
Waikato Hospital /ID# 212789
🇳🇿Hamilton, Waikato, New Zealand
Wellington Regional Hospital /ID# 205343
🇳🇿Newtown, Wellington, New Zealand
Hutt Hospital /ID# 212786
🇳🇿Lower Hutt, New Zealand
Dunedin Hospital /ID# 212790
🇳🇿Otago, New Zealand
Vitamed Gałaj i Cichomski Sp.j. /ID# 213283
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
Vistamed /ID# 210105
🇵🇱Wroclaw, Dolnoslaskie, Poland
Gastromed Sp. z o.o /ID# 230978
🇵🇱Torun, Kujawsko-pomorskie, Poland
Centrum Medyczne Plejady /ID# 170633
🇵🇱Krakow, Malopolskie, Poland
Centro Hosp de Tondela-Viseu /ID# 166053
🇵🇹Viseu, Portugal
Ponce Medical School Foundation /ID# 221244
🇵🇷Ponce, Puerto Rico
San Jorge Children Hospital /ID# 166954
🇵🇷San Juan, Puerto Rico
VA Caribbean Healthcare System /ID# 221245
🇵🇷San Juan, Puerto Rico
Clinica GASTRO MED SRL /ID# 224169
🇷🇴Cluj-Napoca, Cluj, Romania
Sana Monitoring /Id# 224166
🇷🇴Bucharest, Romania
WIP Warsaw IBD Point Profesor Kierkus /ID# 216102
🇵🇱Warsaw, Mazowieckie, Poland
Centrum Zdrowia MDM /ID# 170597
🇵🇱Warszawa, Mazowieckie, Poland
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie Panstwowy Instytut Bada /ID# 170600
🇵🇱Warszawa, Mazowieckie, Poland
NZOZ Vivamed Jadwiga Miecz /ID# 216307
🇵🇱Warszawa, Mazowieckie, Poland
H-T. Centrum Medyczne - Endoterapia /ID# 230979
🇵🇱Tychy, Slaskie, Poland
Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 165580
🇵🇹Guimaraes, Braga, Portugal
Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 166551
🇵🇹Portimão, Faro, Portugal
Centro Hospitalar de Entre Douro e Vouga /ID# 166052
🇵🇹Santa Maria Da Feira, Porto, Portugal
Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 170601
🇵🇱Warszawa, Mazowieckie, Poland
Endoskopia Sp. z o.o. /ID# 170598
🇵🇱Sopot, Pomorskie, Poland
NZOZ All-Medicus /ID# 170596
🇵🇱Katowice, Slaskie, Poland
Hospital Garcia de Orta, EPE /ID# 165583
🇵🇹Almada, Portugal
Centro Hospitalar e Universitario de Coimbra, EPE /ID# 166054
🇵🇹Coimbra, Portugal
Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 165582
🇵🇹Lisboa, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 165581
🇵🇹Porto, Portugal
Fundeni Clinical Institute /ID# 171264
🇷🇴Bucharest, Romania
Fundeni Clinical Institute /ID# 224168
🇷🇴Bucharest, Romania
Duplicate_Centrul Medical Tuculanu SRL /ID# 171268
🇷🇴Timisoara, Romania
Cabinet Particular Policlinic Algomed /ID# 171266
🇷🇴Timișoara, Romania
Interdisctrict Multidisciplinary Hospital /ID# 203335
🇷🇺Anzorey, Kabardino-Balkarskaya Respublika, Russian Federation
GBUZ Allergology and Immunology Center of Ministry of Health of Kabardino-Bal /ID# 233973
🇷🇺Nalchik, Kabardino-Balkarskaya Respublika, Russian Federation
Immanuel Kant Baltic Federal University /ID# 204888
🇷🇺Kaliningrad, Kaliningradskaya Oblast, Russian Federation
Kuzbass Regional Clinical Hospital /ID# 165750
🇷🇺Kemerovo, Kemerovskaya Oblast, Russian Federation
Uninova Medical Center /ID# 229216
🇷🇺Saint Petersburg, Leningradskaya Oblast, Russian Federation
Arsvita Clinic /ID# 208946
🇷🇺Korolev, Moskovskaya Oblast, Russian Federation
Perm Clinical Center of the Federal Medical and Biological Agency /ID# 227457
🇷🇺Perm, Permskiy Kray, Russian Federation
City Clinical Hospital #40 /ID# 203370
🇷🇺Sestroretsk, Sankt-Peterburg, Russian Federation
Regional Clinical Hospital #1 /ID# 165754
🇷🇺Tyumen, Tyumenskaya Oblast, Russian Federation
Clinic of New Technologies of Medicine /ID# 203369
🇷🇺Dzerzhinskiy, Russian Federation
First Moscow State Medical University n.a I.M. Sechenov /ID# 204978
🇷🇺Moscow, Russian Federation
National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 203512
🇷🇺Moscow, Russian Federation
Central Clinical Hospital RZHD Medicine /ID# 204917
🇷🇺Moscow, Russian Federation
Novosibirski Gastrocenter /ID# 229855
🇷🇺Novosibirsk, Russian Federation
Euromedservice /ID# 204892
🇷🇺Pushkin, Russian Federation
International Medical Center SOGAZ /ID# 206727
🇷🇺St. Petersburg, Russian Federation
Ulyanovsk Regional Clinical Hospital /ID# 203368
🇷🇺Ulyanovsk, Russian Federation
Clinical Hosp Center Zvezdara /ID# 200151
🇷🇸Belgrade, Beograd, Serbia
University Clinical Center Serbia /ID# 200152
🇷🇸Belgrade, Beograd, Serbia
Clin Hosp Ctr Bezanijska Kosa /ID# 202059
🇷🇸Belgrade, Beograd, Serbia
Clinical Center Vojvodina /ID# 156910
🇷🇸Novi Sad, Vojvodina, Serbia
Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 224926
🇷🇸Belgrade, Serbia
General Hospital Leskovac /ID# 207226
🇷🇸Leskovac, Serbia
KL Ling Gastroenterology and Liver Clinic /ID# 205738
🇸🇬Singapore, Singapore
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 164347
🇸🇰Banska Bystrica, Slovakia
KM Management, spol. s.r.o. /ID# 206602
🇸🇰Nitra, Slovakia
Fakultna nemocnica s poliklinikou Nove Zamky /ID# 224099
🇸🇰Nove Zamky, Slovakia
GASTRO I., s.r.o. /ID# 164346
🇸🇰Presov, Slovakia
Univ Medical Ctr Ljubljana /ID# 210627
🇸🇮Ljubljana, Slovenia
Farmovs (Pty) Ltd /Id# 207537
🇿🇦Bloemfontein, Free State, South Africa
Clinresco Centers /ID# 239824
🇿🇦Johannesburg, Gauteng, South Africa
Spoke Research Inc /ID# 229905
🇿🇦CAPE TOWN Milnerton, Western Cape, South Africa
Allergy & Immunology (AIU) /ID# 171441
🇿🇦Cape Town, Western Cape, South Africa
Dr JP Wright /ID# 171138
🇿🇦Cape Town, Western Cape, South Africa
Private Practice Dr MN Rajabally /ID# 171137
🇿🇦Cape Town, Western Cape, South Africa
Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 159440
🇪🇸Ferrol, A Coruna, Spain
Hospital de Cabuenes /ID# 170748
🇪🇸Gijon, Asturias, Spain
Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159461
🇪🇸Sabadell, Barcelona, Spain
Hospital Universitario Puerta de Hierro, Majadahonda /ID# 159443
🇪🇸Majadahonda, Madrid, Spain
Hospital Alvaro Cunqueiro CHUVI /ID# 167360
🇪🇸Vigo, Pontevedra, Spain
Hospital Clinic de Barcelona /ID# 159439
🇪🇸Barcelona, Spain
Hospital Universitario Reina Sofia /ID# 167058
🇪🇸Cordoba, Spain
Hospital Universitario La Paz /ID# 159459
🇪🇸Madrid, Spain
Complejo Hospitalario Universitario de Pontevedra /ID# 216182
🇪🇸Pontevedra, Spain
Hospital Universitario de Salamanca /ID# 159446
🇪🇸Salamanca, Spain
Hospital Universitario Virgen Macarena /ID# 159968
🇪🇸Sevilla, Spain
Hospital Universitario Miguel Servet /ID# 159445
🇪🇸Zaragoza, Spain
Alingsas lasarett /ID# 202074
🇸🇪Alingsas, Vastra Gotalands Lan, Sweden
Sahlgrenska University Hospital Molndal /ID# 202843
🇸🇪Molndal, Vastra Gotalands Lan, Sweden
Danderyds sjukhus AB /ID# 202035
🇸🇪Stockholm, Sweden
Universitatsspital Zurich /ID# 202910
🇨🇭Zurich, Zuerich, Switzerland
Inselspital, Universitätsspital Bern /ID# 202911
🇨🇭Bern, Switzerland
Chung Shan Medical University Hospital /ID# 163651
🇨🇳Taichung, Taiwan
China Medical University Hospital /ID# 160189
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital /ID# 163649
🇨🇳Taichung, Taiwan
National Taiwan University Hospital /ID# 162187
🇨🇳Taipei City, Taiwan
Taipei Veterans General Hosp /ID# 163650
🇨🇳Taipei, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 222877
🇨🇳Taoyuan City, Taiwan
Acibadem Kozyatagi Hospital /ID# 213276
🇹🇷Kadikoy, Istanbul, Turkey
Erciyes University Medical Fac /ID# 171291
🇹🇷Melikgazi, Kayseri, Turkey
Ankara Univ Medical Faculty /ID# 167210
🇹🇷Ankara, Turkey
Inonu Universitesi Turgut Ozal /ID# 203981
🇹🇷Battalgazi/malatya, Turkey
Uludag University Medical Faculty /ID# 204182
🇹🇷Bursa, Turkey
Fırat University Medical Facul /ID# 171292
🇹🇷Elazig, Turkey
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 167207
🇹🇷Istanbul, Turkey
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171293
🇹🇷Istanbul, Turkey
Sisli Etfal Train & Res Hosp /ID# 171409
🇹🇷Sisli, Turkey
CNE Regional Clinical Hospital of Ivano-Frankivsk RC /ID# 203367
🇺🇦Ivano-frankivsk, Ukraine
Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 224350
🇺🇦Kherson, Ukraine
Kyiv Municipal Clinical Hospital #18 /ID# 224348
🇺🇦Kyiv, Ukraine
Medical Center "OK!Clinic+" /ID# 205482
🇺🇦Kyiv, Ukraine
CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 224343
🇺🇦Kyiv, Ukraine
Royal Devon University Healthcare NHS Foundation Trust /ID# 157587
🇬🇧Exeter, Devon, United Kingdom
University Hospital Southampton NHS Foundation Trust /ID# 210813
🇬🇧Southampton, Hampshire, United Kingdom
Barts Health NHS Trust /ID# 157590
🇬🇧London, London, City Of, United Kingdom
Barnsley Hospital NHS Foundation Trust /ID# 202770
🇬🇧Barnsley, United Kingdom
Cambridge University Hospitals NHS Foundation Trust /ID# 158040
🇬🇧Cambridge, United Kingdom
NHS Lothian /ID# 208802
🇬🇧Edinburgh, United Kingdom
Liverpool University Hospitals NHS Foundation Trust /ID# 203858
🇬🇧Liverpool, United Kingdom
King's College Hospital NHS Foundation Trust /ID# 158766
🇬🇧London, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 158041
🇬🇧Newcastle upon Tyne, United Kingdom
St George's University Hospitals NHS Foundation Trust /ID# 208378
🇬🇧Tooting, United Kingdom
Southern California Res. Ctr. /ID# 169660
🇺🇸Coronado, California, United States
Hoag Memorial Hosp Presbyterian /ID# 218348
🇺🇸Irvine, California, United States
UC San Diego Health System /ID# 160452
🇺🇸La Jolla, California, United States
United Medical Doctors /ID# 158528
🇺🇸Los Alamitos, California, United States
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 200931
🇺🇸Los Angeles, California, United States
UCSF Center for Colitis and Crohn's Disease /ID# 201210
🇺🇸San Francisco, California, United States
Cedars-Sinai Medical Center-West Hollywood /ID# 163851
🇺🇸West Hollywood, California, United States
Peak Gastroenterology Associates, PC /ID# 165841
🇺🇸Colorado Springs, Colorado, United States
Rocky Mountain Pediatric Gastroenterology /ID# 207174
🇺🇸Lone Tree, Colorado, United States
Medical Research Center of CT /ID# 160311
🇺🇸Hamden, Connecticut, United States
Yale Univ Digestive Diseases /ID# 213179
🇺🇸New Haven, Connecticut, United States
South Lake Pain Institute, Inc /ID# 162878
🇺🇸Clermont, Florida, United States
Ctr for Advanced Gastroenterol /ID# 202811
🇺🇸Maitland, Florida, United States
University of Miami /ID# 160471
🇺🇸Miami, Florida, United States
Coral Research Clinic /ID# 158584
🇺🇸Miami, Florida, United States
South Florida Research Ph I-IV, Inc. /ID# 161848
🇺🇸Miami, Florida, United States
Gastroenterology Group Naples /ID# 165212
🇺🇸Naples, Florida, United States
Advanced Research Institute, Inc /ID# 161938
🇺🇸New Port Richey, Florida, United States
Advent Health /ID# 160433
🇺🇸Orlando, Florida, United States
Endoscopic Research, Inc. /ID# 206711
🇺🇸Orlando, Florida, United States
Omega Research Group /ID# 203059
🇺🇸Orlando, Florida, United States
Lenus Research & Medical Group /ID# 169730
🇺🇸Sweetwater, Florida, United States
Clinical Research Trials of Florida, Inc. /ID# 201783
🇺🇸Tampa, Florida, United States
AdventHealth Tampa /ID# 170503
🇺🇸Tampa, Florida, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 160523
🇺🇸Macon, Georgia, United States
Atlanta Gastroenterology Spec /ID# 161372
🇺🇸Suwanee, Georgia, United States
The University of Chicago Medical Center /ID# 160521
🇺🇸Chicago, Illinois, United States
DM Clinical Research/Southwest /ID# 165012
🇺🇸Oak Lawn, Illinois, United States
Indiana University /ID# 167252
🇺🇸Indianapolis, Indiana, United States
Univ Kansas Med Ctr /ID# 226602
🇺🇸Kansas City, Kansas, United States
Cotton-O'Neil Clinical Res Ctr /ID# 160412
🇺🇸Topeka, Kansas, United States
Robley Rex VA Medical Center /ID# 218648
🇺🇸Louisville, Kentucky, United States
Houma Digestive Health Special /ID# 158317
🇺🇸Houma, Louisiana, United States
Delricht Research /ID# 206815
🇺🇸New Orleans, Louisiana, United States
Nola Research Works, LLC /ID# 161368
🇺🇸New Orleans, Louisiana, United States