Probiotics for the prevention of antibiotic-associated diarrhoea and Clostridium difficile associated diarrhoea
Completed
- Conditions
- Topic: Oral and GastrointestinalSubtopic: Oral and Gastrointestinal (all Subtopics)Disease: GastrointestinalDigestive SystemDiarrhoea
- Registration Number
- ISRCTN19604441
- Lead Sponsor
- Wrightington, Wigan and Leigh NHS Foundation Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 445
Inclusion Criteria
1. Systemic antibiotics
2. Aged 18 years or older, either sex
3. Able to take enteral medication (sachets)
Exclusion Criteria
1. Diarrhoea at screening
2. Unable to take enteral medication
3. Patients on intensive care units
4. Severe immunosuppression (neutropenia, acquired immunodeficiency syndrome [AIDS], congenital immunoparesis, chemotherapy)
5. Risk of endocarditis (artificial heart valves, history of rheumatic heart disease or infective endocarditis)
6. Regular consumption of probiotics until 1 week prior to admission
7. Acute severe pancreatitis
8. Persistent vomiting (two days or more)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method