Clot Formation and Clot Stability in Patients With Severe Haemophilia A
- Conditions
- Hemophilia A
- Registration Number
- NCT00279578
- Lead Sponsor
- University of Aarhus
- Brief Summary
In the present study we are examining the clot formation and clot stability in patients with severe haemophilia A after they receive recombinat factor VIII and after addition of tranexamic acid. Our hypothesis is that addition of tranexamic increases the clot stability. The perpective of the study is to document whether it is relevant to use traneksamic acid in surgery in patients with severe haemophilia A.
- Detailed Description
In the present study we are examining the clot formation and clot stability in patients with severe haemophilia A after they receive recombinat factor VIII and after addition of tranexamic acid. Our hypothesis is that addition of tranexamic increases the clot stability. The perpective of the study is to document whether it is relevant to use traneksamic acid in surgery in patients with severe haemophilia A.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 8
- Severe haemophilia A
- Above 17 years old
- Thrombocyt count above 100 x 109/l within the past two years
- Received recombinant factor VIII with in the past 3 days
- Inhibitor against recombinant factor VIII
- HIV-positive
- Ongoing treatment for hepatitis C
- Known kidney disease
- Allergy against Tranexamic acid
- Not able to give informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Clot stability
- Secondary Outcome Measures
Name Time Method clot formation,thrombine generation
Trial Locations
- Locations (1)
Department of Clinical Biochemistry, Center for Haemophilia and Thrombosis
🇩🇰Aarhus, Denmark