A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis

Completed

• Conditions: Generalized Chronic Periodontitis; Osteoporosis
• Interventions: Genetic: CTR Gene

• Registration Number: NCT02273128
• Lead Sponsor: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Brief Summary

Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.

Detailed Description

Periodontitis is a polymicrobial inflammatory disease which includes various modifiable and nonmodifiable risk factors. The non modifiable risk factors include genetic polymorphisms like metabolism associated genetic polymorphisms ( Vitamin D and Calcitonin).

Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue with consequent increase in bone fragility and susceptibility to fractures.

Bone loss is a common feature shared between periodontal disease and osteoporosis.

Out of all genetic factors Calcitonin gene polymorphism contributes to the development of both osteoporosis and chronic periodontitis.

Study Timeline

• Study Start: 2014-06
• Primary Completion: 2014-10
• Study First Submitted: 2014-10-21
• Study First Submitted QC: 2014-10-22
• Study First Posted: 2014-10-23
• Study Completion: 2014-11
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-18
• Last Update Posted: 2015-04-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Male and Female
• Patients aged between 35.00 Year(s) to 60.00 Year(s) diagnosed with Osteoporosis and Chronic Periodontitis who are willing to participate in the study

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Exclusion Criteria

• Patients who are Systemically compromised and under medications such as steroids.
• Patients who smoke.Pregnant and lactating mothers are excluded from the study

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
CTR Gene in Osteoporosis and Periodontitis	CTR Gene	Patients aged between 35 - 60 yrs with Osteoporosis (BMD\>-2.5) and Chronic Periodontitis (\>3mm Pocket Probing Depth)

Primary Outcome Measures

Name	Time	Method
Calcitonin gene polymorphism	5 Months	Collection of blood samples and running the samples by PCR

Trial Locations

Locations (1)

Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre; 🇮🇳 Hyderabad, Andhra Pradesh, India