To study the efficacy of administration of metformin into thyroid nodules and compare it with oral metformin in patients with benign goiter and normal thyroid functio
Phase 2
- Conditions
- Health Condition 1: E049- Nontoxic goiter, unspecified
- Registration Number
- CTRI/2019/07/020053
- Lead Sponsor
- IPGMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Age 18 years and above
2. Consecutive patients with thyroid nodules <4cm
3. Clinically and biochemically euthyroid
Exclusion Criteria
1. History of intake of levothyroxine/metformin
2. Any ultrasound or FNA evidence of thyroid malignancy
3. Nodules causing compressive symptoms
4. Coalescent thyroid nodules (not suitable for size analysis)
5. HbA1c >7.5%
6. History of significant neurological or psychiatric illness which may influence thyroid function
7. Iodinated contrast exposure within past 6months
8. History of neck irradiation or neck surgery
9. Use of any medication that would affect thyroid functions
10. Pregnancy or lactation
11. Creatinine levels > 1.4 mg/dL
12. Hepatic or cardiac insufficiency
13.History of malignancies
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in the nodule volumeTimepoint: Baseline,at 3 months and at 6 months <br/ ><br>
- Secondary Outcome Measures
Name Time Method Change in the TSH and thyroid hormones from baseline <br/ ><br>Timepoint: 6months