The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Concentration During General Anesthesia Induction
Overview
- Phase
- Phase 4
- Intervention
- 1% lidocaine
- Conditions
- Target Controlled Infusion (TCI)
- Sponsor
- First Hospital of China Medical University
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- The Effect-site Concentration of Propofol
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
It is a prospective, randomized, placebo-controlled study to investigate the effect of TEA with different block level on propofol concentration during general anesthesia induction.
Investigators
Jun Wang
professor
First Hospital of China Medical University
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists (ASA) I-II physical status,
- •aged 40-60 yr,
- •BMI 19-25 kg/m2,
- •undergoing elective gastrointestinal surgery
Exclusion Criteria
- •patients with cardiovascular or neurological disease, drug or alcohol abuse and absolute contraindications for neuraxial blockade.
Arms & Interventions
1% lidocaine
epidural anesthesia with 1% lidocaine 10ml before propofol TCI
Intervention: 1% lidocaine
2% lidocaine
epidural anesthesia with 2% lidocaine 5ml before propofol TCI
Intervention: 2% lidocaine
0.9% normal saline
epidural anesthesia with 0.9% normal saline 5ml before propofol TCI
Intervention: 0.9% normal saline
Outcomes
Primary Outcomes
The Effect-site Concentration of Propofol
Time Frame: The participants will be followed for the duration of anesthesia induction, an expected average of half an hour
The effect-site concentration of propofol when loss of consciousness during propofol target-controlled infusing(TCI) induction of anesthesia.
Secondary Outcomes
- The Bispectral Index(The participants will be followed for the duration of anesthesia induction, an expected average of half an hour)
- The Mean Blood Pressure(The participants will be followed for the duration of anesthesia induction, an expected average of half an hour)
- The Heart Rate(The participants will be followed for the duration of anesthesia induction, an expected average of half an hour)
- The Block Level of Epidural Anesthesia(20 mins after epidural anesthesia)