Effects of Thoracic Epidural Anesthesia With Different Local Anesthetics on Propofol Induction
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 主要终点
- Propofol Effect-site Concentration
研究概览
简要总结
The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Surgery for thoracotomies, BMI: 18-25 Kg/m2, American Society of Anesthesiologists(ASA) classification I or II.
排除标准
- •liver or kidney disease, alcohol dependence, take sedative recently, contraindications for epidural anesthesia.
研究组 & 干预措施
Normal saline
General anesthesia combined with thoracic epidural 0.9% normal saline 8ml
干预措施: Normal Saline (Drug)
Lidocaine
General anesthesia combined with thoracic epidural 1% lidocaine 8ml
干预措施: Lidocaine (Drug)
Bupivacaine
General anesthesia combined with thoracic epidural 0.25% bupivacaine 8ml
干预措施: Bupivacaine (Drug)
Ropivacaine
General anesthesia combined with thoracic epidural 0.3% ropivacaine 8ml
干预措施: Ropivacaine (Drug)
结局指标
主要结局
Propofol Effect-site Concentration
时间窗: Before starting anesthesia to finishing endotracheal intubation
The effect-site concentration of propofol when loss of consciousness during propofol target-controlled infusing(TCI) induction of anesthesia.
次要结局
- Heart Rate(Before starting anesthesia to finishing endotracheal intubation)
- Bispectral Index Score(Before starting anesthesia to finishing endotracheal intubation)
- Mean Arterial Pressure(Before starting anesthesia to finishing endotracheal intubation)
研究者
Jun Wang
Professor
First Hospital of China Medical University