Effects of Thoracic Epidural Anesthesia With Different Local Anesthetics on Propofol Induction
Overview
- Phase
- Phase 4
- Intervention
- Normal Saline
- Conditions
- General Anesthesia
- Sponsor
- First Hospital of China Medical University
- Enrollment
- 80
- Primary Endpoint
- Propofol Effect-site Concentration
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.
Investigators
Jun Wang
Professor
First Hospital of China Medical University
Eligibility Criteria
Inclusion Criteria
- •Surgery for thoracotomies, BMI: 18-25 Kg/m2, American Society of Anesthesiologists(ASA) classification I or II.
Exclusion Criteria
- •liver or kidney disease, alcohol dependence, take sedative recently, contraindications for epidural anesthesia.
Arms & Interventions
Normal saline
General anesthesia combined with thoracic epidural 0.9% normal saline 8ml
Intervention: Normal Saline
Lidocaine
General anesthesia combined with thoracic epidural 1% lidocaine 8ml
Intervention: Lidocaine
Bupivacaine
General anesthesia combined with thoracic epidural 0.25% bupivacaine 8ml
Intervention: Bupivacaine
Ropivacaine
General anesthesia combined with thoracic epidural 0.3% ropivacaine 8ml
Intervention: Ropivacaine
Outcomes
Primary Outcomes
Propofol Effect-site Concentration
Time Frame: Before starting anesthesia to finishing endotracheal intubation
The effect-site concentration of propofol when loss of consciousness during propofol target-controlled infusing(TCI) induction of anesthesia.
Secondary Outcomes
- Heart Rate(Before starting anesthesia to finishing endotracheal intubation)
- Bispectral Index Score(Before starting anesthesia to finishing endotracheal intubation)
- Mean Arterial Pressure(Before starting anesthesia to finishing endotracheal intubation)